<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1889-836X</journal-id>
<journal-title><![CDATA[Revista de Osteoporosis y Metabolismo Mineral]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Osteoporos Metab Miner]]></abbrev-journal-title>
<issn>1889-836X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Española de Investigaciones Óseas y Metabolismo Mineral]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1889-836X2024000200004</article-id>
<article-id pub-id-type="doi">10.20960/revosteoporosmetabminer.00043</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Desafíos en el diagnóstico y tratamiento de los tumores pardos: características clínico-radiológicas en una serie de casos y revisión de la literatura]]></article-title>
<article-title xml:lang="en"><![CDATA[Challenges in the diagnosis and treatment of brown tumors &#8211; Clinical radiological features in a case series and review of the literature]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández-Guevara]]></surname>
<given-names><![CDATA[Jorge]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Salcedo-Rodríguez]]></surname>
<given-names><![CDATA[Germán]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Varela]]></surname>
<given-names><![CDATA[Andrés Felipe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Micolta-Córdoba]]></surname>
<given-names><![CDATA[Lina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Marulanda-Ibarra]]></surname>
<given-names><![CDATA[Elizabeth]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Kafury]]></surname>
<given-names><![CDATA[Daniel Felipe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad del Valle Servicio de Ortopedia y Traumatología ]]></institution>
<addr-line><![CDATA[Santiago de Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Unidad de Ortopedia Oncológica. Fundación Valle del Lili Servicio de Ortopedia y Traumatología ]]></institution>
<addr-line><![CDATA[Santiago de Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad del Valle Servicio de Geriatría ]]></institution>
<addr-line><![CDATA[Santiago de Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Nacional Servicio de Anestesiología ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad Icesi Escuela de Medicina ]]></institution>
<addr-line><![CDATA[Santiago de Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2024</year>
</pub-date>
<volume>16</volume>
<numero>2</numero>
<fpage>61</fpage>
<lpage>66</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1889-836X2024000200004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1889-836X2024000200004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1889-836X2024000200004&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: los tumores pardos son el resultado de la alteración del metabolismo óseo debido al hiperparatiroidismo primario, secundario o terciario. Su relevancia recae en el aumento del riesgo de fracturas patológicas, dolor, incapacidad y limitación funcional que pueden producir.  Casos clínicos y discusión: se realiza un reporte tipo serie casos constituida por 3 pacientes con hiperparatiroidismo secundario por enfermedad renal crónica (ERC) sin diagnóstico ni tratamiento que sufrieron fracturas patológicas presentados en un hospital de referencia del suroccidente colombiano; se exponen las características clínicas, radiológicas y quirúrgicas. Del mismo modo, se realiza una revisión crítica de la literatura en relación al hiperparatiroidismo secundario por ERC con el fin de resaltar la importancia de la sospecha diagnóstica, pues cerca de 1 de cada 3 pacientes con ERC en estadios avanzados desarrollarán hiperparatiroidismo secundario y esto conlleva un alto riesgo de fracturas patológicas asociadas con toda la morbilidad que implican.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: brown tumors result from changes in bone metabolism due to primary, secondary, or tertiary hyperparathyroidism. Their significance lies in the increased risk of pathological fractures, pain, disability, and functional limitation they can cause.  Case reports and discussion: this case series report presents 3 patients with secondary hyperparathyroidism due to chronic kidney disease (CKD) who had not been diagnosed or treated and had sustained pathological fractures. These cases were presented at a referral hospital in southwestern Colombia. The clinical, radiological, and surgical characteristics are described. Additionally, a critical literature review is conducted on secondary CKD-related hyperparathyroidism to emphasize the importance of diagnostic suspicion, as nearly 1 in 3 patients with advanced-stage CKD will develop secondary hyperparathyroidism, leading to a high risk of pathological fractures associated with significant morbidity.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Tumores pardos]]></kwd>
<kwd lng="es"><![CDATA[Osteítis fibrosa quística]]></kwd>
<kwd lng="es"><![CDATA[Hiperparatiroidismo secundario]]></kwd>
<kwd lng="es"><![CDATA[Fracturas patológicas]]></kwd>
<kwd lng="en"><![CDATA[Brown tumors]]></kwd>
<kwd lng="en"><![CDATA[Osteitis fibrosa cystica]]></kwd>
<kwd lng="en"><![CDATA[Secondary hyperparathyroidism]]></kwd>
<kwd lng="en"><![CDATA[Pathological fractures]]></kwd>
</kwd-group>
</article-meta>
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