<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1889-836X</journal-id>
<journal-title><![CDATA[Revista de Osteoporosis y Metabolismo Mineral]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Osteoporos Metab Miner]]></abbrev-journal-title>
<issn>1889-836X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Española de Investigaciones Óseas y Metabolismo Mineral]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1889-836X2024000400004</article-id>
<article-id pub-id-type="doi">10.20960/revosteoporosmetabminer.00061</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Proteómica aplicada al estudio de la calcificación vascular en la enfermedad renal crónica]]></article-title>
<article-title xml:lang="en"><![CDATA[Proteomics applied to the study of vascular calcification in chronic kidney disease]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quirós-Caso]]></surname>
<given-names><![CDATA[Covadonga]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carrillo-López]]></surname>
<given-names><![CDATA[Natalia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="Ab"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández-Martín]]></surname>
<given-names><![CDATA[José Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="Ab"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alonso-Montes]]></surname>
<given-names><![CDATA[Cristina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="Ab"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cannata-Andía]]></surname>
<given-names><![CDATA[Jorge B]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Universitario Central de Asturias Servicio de Bioquímica Laboratorio de Medicina]]></institution>
<addr-line><![CDATA[Oviedo ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Universitario Central de Asturias Unidad de Gestión Clínica del Metabolismo Óseo Metabolismo Óseo, Vascular y Enfermedades Inflamatorias Crónicas. Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)]]></institution>
<addr-line><![CDATA[Oviedo ]]></addr-line>
<country>España</country>
</aff>
<aff id="A2b">
<institution><![CDATA[,Instituto de Salud Carlos III RED DE INVESTIGACION RENAL Redes de Investigación Cooperativa Orientadas a Resultados en Salud]]></institution>
<addr-line><![CDATA[Oviedo ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Oviedo Departamento de Medicina ]]></institution>
<addr-line><![CDATA[Oviedo ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<volume>16</volume>
<numero>4</numero>
<fpage>140</fpage>
<lpage>148</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1889-836X2024000400004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1889-836X2024000400004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1889-836X2024000400004&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: la calcificación vascular (CV) se asocia a un incremento de la mortalidad en la población general y en pacientes con enfermedad renal crónica, en los que la prevalencia es mucho mayor. La necesidad de un diagnóstico efectivo y precoz de la CV para mejorar las estrategias preventivas y pronósticas ha impulsado la investigación sobre biomarcadores. El objetivo de este trabajo es estudiar la expresión diferencial de proteínas asociadas al proceso de CV mediante técnicas de proteómica.  Material y métodos: se cultivaron células de músculo liso vascular en condiciones no calcificantes y calcificantes. La expresión diferencial de proteica se realizó mediante 2D-DIGE y LC-ESI-MS/MS y la identificación se realizó con el motor MASCOT.  Resultados: tras seis días de cultivo, se detectaron 121 spots de proteínas expresadas diferencialmente. De estas proteínas, 21 fueron identificadas en 24 spots. En las células cultivadas en medio calcificante, cuatro proteínas aumentaron significativamente su expresión; la del colágeno de tipo I fue la que mostró un mayor cambio (3,49 veces) respecto a las cultivadas en medio no calcificante. Otras proteínas, musculares y estructurales, mostraron una reducción en su expresión. Además, se observaron cambios en la expresión de nucleobindina-1 y endoplasmina que hasta la fecha no se habían relacionado con la CV.  Conclusión: los resultados confirmaron el descenso en la expresión de proteínas típicamente musculares y del citoesqueleto durante la CV. Además, se identificaron cambios en la expresión de proteínas que previamente no se habían relacionado con la CV y que podrían estar implicados en este proceso.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: vascular calcification (VC) is associated with increased mortality in the general population, as well as in patients with chronic kidney disease, in whom prevalence is much higher. The need for effective and early diagnosis of VC to improve preventive and prognostic strategies has driven research on biomarkers. The aim of this study is to examine the differential expression of proteins associated with the VC process using proteomics techniques.  Materials and methods: vascular smooth muscle cells were cultured under non-calcifying and calcifying conditions. Differential protein expression was performed using 2D-DIGE and LC-ESI-MS/MS, and identification was conducted using with the MASCOT search engine.  Results: after 6 days of culture, a total of 121 protein spots with differential expression were detected. A total 21 out of all these proteins were identified in 24 spots. In the cells cultured in the calcifying medium, a total of 4 showed a significantly increased expression; collagen type I exhibited the greatest change (3.49 times) vs those cultured in a non-calcifying medium. Other muscle and structural proteins showed a decrease in their expression. Furthermore, changes were reported in the expression of nucleobindin-1 and endoplasmin, which had not previously been associated with VC.  Conclusion: the results confirmed the reduction in the expression of typical muscle and cytoskeletal proteins during VC. Additionally, changes in the expression of proteins that had not previously been associated with VC were identified, and these may be involved in the process.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Calcificación vascular]]></kwd>
<kwd lng="es"><![CDATA[Enfermedad renal crónica]]></kwd>
<kwd lng="es"><![CDATA[Proteómica]]></kwd>
<kwd lng="es"><![CDATA[2D-DIGE]]></kwd>
<kwd lng="en"><![CDATA[Vascular calcification]]></kwd>
<kwd lng="en"><![CDATA[Chronic kidney disease]]></kwd>
<kwd lng="en"><![CDATA[Proteomics]]></kwd>
<kwd lng="en"><![CDATA[2D-DIGE]]></kwd>
</kwd-group>
</article-meta>
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<article-title xml:lang=""><![CDATA[Proteomics analysis of human coronary atherosclerotic plaque: a feasibility study of direct tissue proteomics by liquid chromatography and tandem mass spectrometry]]></article-title>
<source><![CDATA[Mol Cell Proteomics]]></source>
<year>2007</year>
<volume>6</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1088-102</page-range></nlm-citation>
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</back>
</article>
