<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1889-836X</journal-id>
<journal-title><![CDATA[Revista de Osteoporosis y Metabolismo Mineral]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Osteoporos Metab Miner]]></abbrev-journal-title>
<issn>1889-836X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Española de Investigaciones Óseas y Metabolismo Mineral]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1889-836X2026000100028</article-id>
<article-id pub-id-type="doi">10.20960/revosteoporosmetabminer.00104</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Las glándulas paratiroides: dos siglos de investigación al servicio de la clínica]]></article-title>
<article-title xml:lang="en"><![CDATA[The parathyroid glands &#8212; Two centuries of research at the service of clinical practice]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Millán]]></surname>
<given-names><![CDATA[Marta Martín]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Cantabria. IDIVAL Hospital Universitario Marqués de Valdecilla Servicio de Medicina Interna]]></institution>
<addr-line><![CDATA[Santander ]]></addr-line>
<country>Spain</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2026</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2026</year>
</pub-date>
<volume>18</volume>
<numero>1</numero>
<fpage>28</fpage>
<lpage>36</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S1889-836X2026000100028&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S1889-836X2026000100028&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S1889-836X2026000100028&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El descubrimiento de las glándulas paratiroides y, años más tarde, su potencial terapéutico es un excelente ejemplo en la historia de la medicina acerca del papel de los trabajos de investigación básica en la proyección de la práctica médica. Un ejemplo excelente pues se trata de un tema que ha estado lleno de interpretaciones enfrentadas, de polémicas y de ensayos fallidos hasta llegar a la situación en que, en el año 2002, la U.S. Food and Drug Administration (FDA) aprobó la utilización del fragmento 1-34 de la hormona paratiroidea humana (hPTH) para el tratamiento de la osteoporosis en hombres y mujeres posmenopáusicas con alto riesgo de fractura. A partir de ahí su uso se generalizó y se consolidó en la práctica clínica habitual. Pero no ha sido fácil llegar hasta esa situación. Durante casi 200 años y a través de sucesivas observaciones, llevadas a cabo tanto en el laboratorio como en el ámbito clínico, se ha podido alcanzar una visión completa de la verdadera función de un órgano al principio poco conocido. En el presente trabajo me propongo explicar brevemente y pasar revista a los momentos históricos más destacados del conocimiento de la citada glándula y su hormona, así como de su utilización posterior. Este capítulo de la historia de la medicina merece ser recordado pues ilustra muy bien, el proceso colectivo de aprendizaje y de cómo la acumulación de observaciones seguidas de reflexión, debate y discusión constructiva nos lleva a profundizar en el conocimiento de fenómenos y realidades antes poco o nada conocidas. Un conocimiento del que, como bien se ve en este ejemplo &#8211;obviamente extrapolable a muchos otros&#8211; tarde o temprano la sociedad siempre sale beneficiada.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The discovery of the parathyroid glands and, years later, their therapeutic potential represents an outstanding example in the history of medicine of the role of basic research in shaping clinical practice. It is an excellent example because it is a subject that has been marked by conflicting interpretations, controversies, and failed trials, until reaching the point where, in 2002, the U.S. Food and Drug Administration (FDA) approved the use of the 1-34 fragment of human parathyroid hormone (hPTH) for the treatment of osteoporosis in men and postmenopausal women at high risk of fracture. From that moment onward, its use became widespread and consolidated in routine clinical practice. However, reaching this point was far from straightforward. Over nearly 200 years, through successive observations carried out both in the laboratory and in the clinical setting, it has been possible to achieve a comprehensive understanding of the true function of an organ that was initially poorly understood. In this paper, I aim to briefly explain and review the most significant historical milestones in the understanding of the parathyroid glands and their hormone, as well as their subsequent clinical application. This chapter in the history of medicine deserves to be remembered, as it clearly illustrates the collective learning process and how the accumulation of observations, followed by reflection, debate, and constructive discussion, leads to deeper knowledge of phenomena and realities that were previously little known or entirely unknown. Knowledge from which&#8212;clearly demonstrated in this example and readily extrapolated to many others&#8212;society ultimately always benefits.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Glándulas paratiroides]]></kwd>
<kwd lng="es"><![CDATA[Hiperparatiroidismo]]></kwd>
<kwd lng="es"><![CDATA[Hipercalcemia]]></kwd>
<kwd lng="es"><![CDATA[Hormona paratiroidea]]></kwd>
<kwd lng="en"><![CDATA[Parathyroid glands]]></kwd>
<kwd lng="en"><![CDATA[Hyperparathyroidism]]></kwd>
<kwd lng="en"><![CDATA[Hypercalcemia]]></kwd>
<kwd lng="en"><![CDATA[Parathyroid hormone]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Owen]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[On the Anatomy of the Indian Rhinoceros (Rhunicornis, L.)]]></article-title>
<source><![CDATA[Zool Soc]]></source>
<year>1852</year>
<volume>IV</volume>
<page-range>31-58</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sandström]]></surname>
<given-names><![CDATA[IV]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[On a new gland in man and several mammals &#8211;glandulae parathyroideae]]></article-title>
<source><![CDATA[Upsala LäkFörenings Förh]]></source>
<year>1879</year>
<volume>80</volume>
<numero>15</numero>
<issue>15</issue>
<page-range>441-71</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gley]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sur Les fonctions du corps thyroid]]></article-title>
<source><![CDATA[CR SocBiol (Paris)]]></source>
<year>1891</year>
<volume>43</volume>
<page-range>841-7</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Erdheim]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tetaniaparathyreopriva]]></article-title>
<source><![CDATA[Mitt Grenzgeb Med Chir]]></source>
<year>1906</year>
<volume>16</volume>
<page-range>632-744</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Maccallum]]></surname>
<given-names><![CDATA[WG]]></given-names>
</name>
<name>
<surname><![CDATA[Voegtlin]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[On the relation of tetany to the parathyroid glands and to calcium metabolism]]></article-title>
<source><![CDATA[J Exp Med]]></source>
<year>1909</year>
<volume>11</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>118-51</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Collip]]></surname>
<given-names><![CDATA[JB]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The extraction of a parathyroid hormone which will prevent or control parathyroid tetany and which regulates the level of blood calcium]]></article-title>
<source><![CDATA[J Biol Chem]]></source>
<year>1925</year>
<volume>63</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>395-438</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Recklinghausen]]></surname>
<given-names><![CDATA[VF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diefibröseoderdeformierende Ostitis, die Osteomalacie und die osteoplastische Carcinose in Ihrengegenseitigen Beziehungen]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Festschrift]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Virchow zuseinem 71. Geburtstage. G. Reimer, Berlin]]></source>
<year>1891</year>
</nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schlagenhaufer]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[ZweiFälle von Parathyreoideatumoren]]></article-title>
<source><![CDATA[Wien Klin Wochenschr]]></source>
<year>1915</year>
<volume>28</volume>
<page-range>1362</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mandl]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Attempt to treat generalized fibrous osteitis by extirpation of parathyroid tumor]]></article-title>
<source><![CDATA[Zentralbl F Chir]]></source>
<year>1926</year>
<volume>53</volume>
<page-range>260-4</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Albright]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Reifenstein Jr]]></surname>
<given-names><![CDATA[EC]]></given-names>
</name>
</person-group>
<source><![CDATA[The Parathyroid glands and metabolic bone disease:selected studies]]></source>
<year>1948</year>
<publisher-loc><![CDATA[Baltimore, MD ]]></publisher-loc>
<publisher-name><![CDATA[Williams &amp;Wilkins]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Albright]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Bauer]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Ropes]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Aub]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Studies of calcium and phosphorusmetabolism]]></article-title>
<source><![CDATA[IV. The effects of theparathyroid hormone. J Clin Invest]]></source>
<year>1929</year>
<volume>7</volume>
<page-range>139</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bauer]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Aub]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[Albright]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Studies of calcium and Phosphorus metabolism:V. A study of the bone trabeculae as a readily available reserve supply of calcium]]></article-title>
<source><![CDATA[J Exp Med]]></source>
<year>1929</year>
<volume>49</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>145-62</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cope]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Story of Hyperparathyroidism at the Massachusetts General Hospital]]></article-title>
<source><![CDATA[N Engl J Med]]></source>
<year>1966</year>
<volume>274</volume>
<page-range>1174-82</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hunter]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Aub]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lead Studies. XV. The Effect of the Parathyroid Hormone on the Excretion of Lead and of Calcium in Patients Suffering from Lead Poisoning]]></article-title>
<source><![CDATA[Int J Med]]></source>
<year>1927</year>
<volume>20</volume>
<numero>78</numero>
<issue>78</issue>
<page-range>123-40</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hannon]]></surname>
<given-names><![CDATA[RR]]></given-names>
</name>
<name>
<surname><![CDATA[Shorr]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[McClellan]]></surname>
<given-names><![CDATA[WS]]></given-names>
</name>
<name>
<surname><![CDATA[DuBois]]></surname>
<given-names><![CDATA[EF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A case of osteitis fibrosa Cystica (Osteomalacia?) with evidence of hyperactivity of the para-thyroid bodies, Metabolic Study I]]></article-title>
<source><![CDATA[J Clin Invest]]></source>
<year>1930</year>
<volume>8</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>215-27</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Casper]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inexplicable patients:the case of Charles Martell and Ward 4 at the Massachusetts General Hospital]]></article-title>
<source><![CDATA[CMAJ]]></source>
<year>2016</year>
<volume>188</volume>
<numero>(17-18)</numero>
<issue>(17-18)</issue>
<page-range>1263-4</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bauer]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Albright]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Aub]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A case of osteitis fibrosa Cystica (Osteomalacia?) with evidence of hyperactivity of the para-thyroid bodies, Metabolic Study II]]></article-title>
<source><![CDATA[J Clin Invest]]></source>
<year>1930</year>
<volume>8</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>229-48</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Selye]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[On the stimulation of new bone-formation with parathyroid extract and irradiated ergosterol]]></article-title>
<source><![CDATA[Endocrinology]]></source>
<year>1932</year>
<volume>16</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>547-58</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pugsley]]></surname>
<given-names><![CDATA[LI]]></given-names>
</name>
<name>
<surname><![CDATA[Selye]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The histological changes in the bone responsible for the action of parathyroid hormone on the calcium metabolism of the rat]]></article-title>
<source><![CDATA[J Physiol]]></source>
<year>1933</year>
<volume>79</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>113-7</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Parsons]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Reit]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chronic response of dogs to parathyroid hormone infusion]]></article-title>
<source><![CDATA[Nature]]></source>
<year>1974</year>
<volume>250</volume>
<numero>463</numero>
<issue>463</issue>
<page-range>254-7</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reeve]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Tregear]]></surname>
<given-names><![CDATA[GW]]></given-names>
</name>
<name>
<surname><![CDATA[Parsons]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Preliminary Trial of Low Doses of Human Parathyroid Hormone 1-34 Peptide in Treatment of Osteoporosis]]></article-title>
<source><![CDATA[Calcified Tissues]]></source>
<year>1975</year>
</nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reeve]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Meunier]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
<name>
<surname><![CDATA[Parsons]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Bernat]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Bijvoet]]></surname>
<given-names><![CDATA[OL]]></given-names>
</name>
<name>
<surname><![CDATA[Courpron]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Anabolic effect of human parathyroid hormone fragment on trabecular bone in involutional osteoporosis:a multicentre trial]]></article-title>
<source><![CDATA[Br Med J]]></source>
<year>1980</year>
<volume>280</volume>
<numero>6228</numero>
<issue>6228</issue>
<page-range>1340-4</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Neer]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
<name>
<surname><![CDATA[Arnaud]]></surname>
<given-names><![CDATA[CD]]></given-names>
</name>
<name>
<surname><![CDATA[Zanchetta]]></surname>
<given-names><![CDATA[JR]]></given-names>
</name>
<name>
<surname><![CDATA[Prince]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Gaich]]></surname>
<given-names><![CDATA[GA]]></given-names>
</name>
<name>
<surname><![CDATA[Reginster]]></surname>
<given-names><![CDATA[JY]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis]]></article-title>
<source><![CDATA[N Engl J Med]]></source>
<year>2001</year>
<volume>344</volume>
<numero>19</numero>
<issue>19</issue>
<page-range>1434-41</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martin]]></surname>
<given-names><![CDATA[TJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Historically significant events in the discovery of RANK/RANKL/OPG]]></article-title>
<source><![CDATA[World J Orthop]]></source>
<year>2013</year>
<volume>4</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>186-97</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jilka]]></surname>
<given-names><![CDATA[RL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Molecular and cellular mechanisms of the anabolic effect of intermittent PTH]]></article-title>
<source><![CDATA[Bone]]></source>
<year>2007</year>
<volume>40</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1434-46</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jilka]]></surname>
<given-names><![CDATA[RL]]></given-names>
</name>
<name>
<surname><![CDATA[O'Brien]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Ali]]></surname>
<given-names><![CDATA[AA]]></given-names>
</name>
<name>
<surname><![CDATA[Roberson]]></surname>
<given-names><![CDATA[PK]]></given-names>
</name>
<name>
<surname><![CDATA[Weinstein]]></surname>
<given-names><![CDATA[RS]]></given-names>
</name>
<name>
<surname><![CDATA[Manolagas]]></surname>
<given-names><![CDATA[SC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intermittent PTH stimulates periosteal bone formation by actions on post-mitotic preosteoblasts]]></article-title>
<source><![CDATA[Bone]]></source>
<year>2009</year>
<volume>44</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>275-86</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bellido]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Ali]]></surname>
<given-names><![CDATA[AA]]></given-names>
</name>
<name>
<surname><![CDATA[Plotkin]]></surname>
<given-names><![CDATA[LI]]></given-names>
</name>
<name>
<surname><![CDATA[Fu]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
<name>
<surname><![CDATA[Gubrij]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Roberson]]></surname>
<given-names><![CDATA[PK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism]]></article-title>
<source><![CDATA[J Biol Chem]]></source>
<year>2003</year>
<volume>278</volume>
<numero>50</numero>
<issue>50</issue>
<page-range>50259-72</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[SW]]></given-names>
</name>
<name>
<surname><![CDATA[Pajevic]]></surname>
<given-names><![CDATA[PD]]></given-names>
</name>
<name>
<surname><![CDATA[Selig]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Barry]]></surname>
<given-names><![CDATA[KJ]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[JY]]></given-names>
</name>
<name>
<surname><![CDATA[Shin]]></surname>
<given-names><![CDATA[CS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intermittent parathyroid hormone administration converts quiescent lining cells to active osteoblasts]]></article-title>
<source><![CDATA[J Bone Miner Res]]></source>
<year>2012</year>
<volume>27</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>2075-84</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bellido]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Ali]]></surname>
<given-names><![CDATA[AA]]></given-names>
</name>
<name>
<surname><![CDATA[Gubrij]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Plotkin]]></surname>
<given-names><![CDATA[LI]]></given-names>
</name>
<name>
<surname><![CDATA[Fu]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
<name>
<surname><![CDATA[O'Brien]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes:a novel mechanism for hormonal control of osteoblastogenesis]]></article-title>
<source><![CDATA[Endocrinology]]></source>
<year>2005</year>
<volume>146</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>4577-83</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pazianas]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Anabolic effects of PTH and the 'anabolic window']]></article-title>
<source><![CDATA[Trends Endocrinol Metab]]></source>
<year>2015</year>
<volume>26</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>111-3</page-range></nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Abou-Samra]]></surname>
<given-names><![CDATA[AB]]></given-names>
</name>
<name>
<surname><![CDATA[Jüppner]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Force]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Freeman]]></surname>
<given-names><![CDATA[MW]]></given-names>
</name>
<name>
<surname><![CDATA[Kong]]></surname>
<given-names><![CDATA[XF]]></given-names>
</name>
<name>
<surname><![CDATA[Schipani]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Structure, function, and expression of the receptor for parathyroid hormone and parathyroid hormone-related peptide]]></article-title>
<source><![CDATA[Adv Nephrol Necker Hosp]]></source>
<year>1994</year>
<volume>23</volume>
<page-range>247-64</page-range></nlm-citation>
</ref>
<ref id="B32">
<label>32</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martin]]></surname>
<given-names><![CDATA[TJ]]></given-names>
</name>
<name>
<surname><![CDATA[Sims]]></surname>
<given-names><![CDATA[NA]]></given-names>
</name>
<name>
<surname><![CDATA[Seeman]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Physiological and pharmacological roles of PTH and PTHrP in bone using their shared receptor, PTH1R]]></article-title>
<source><![CDATA[Endocr Rev]]></source>
<year>2021</year>
<volume>42</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>383-406</page-range></nlm-citation>
</ref>
<ref id="B33">
<label>33</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Esbrit]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Papel de la proteína relacionada con la parathormona (PTHrP) en el metabolismo óseo:de la investigación básica a la clínica]]></article-title>
<source><![CDATA[Rev Osteoporos Metab Miner]]></source>
<year>2023</year>
<volume>15</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-5</page-range></nlm-citation>
</ref>
<ref id="B34">
<label>34</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wein]]></surname>
<given-names><![CDATA[MN]]></given-names>
</name>
<name>
<surname><![CDATA[Kronenberg]]></surname>
<given-names><![CDATA[HM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Regulation of bone remodeling by parathyroid hormone]]></article-title>
<source><![CDATA[Cold Spring Harb Perspect Med]]></source>
<year>2018</year>
<volume>8</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>a031237</page-range></nlm-citation>
</ref>
<ref id="B35">
<label>35</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ardura]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Portal-Núñez]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Alonso]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Bravo]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Gortazar]]></surname>
<given-names><![CDATA[AR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Handling parathormone receptor type 1 in skeletal diseases:realities and expectations of abaloparatide]]></article-title>
<source><![CDATA[Trends Endocrinol Metab]]></source>
<year>2019</year>
<volume>30</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>756-66</page-range></nlm-citation>
</ref>
<ref id="B36">
<label>36</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wein]]></surname>
<given-names><![CDATA[MN]]></given-names>
</name>
<name>
<surname><![CDATA[Foretz]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Fisher]]></surname>
<given-names><![CDATA[DE]]></given-names>
</name>
<name>
<surname><![CDATA[Xavier]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
<name>
<surname><![CDATA[Kronenberg]]></surname>
<given-names><![CDATA[HM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Salt-inducible kinases:physiology, regulation by cAMP, and therapeutic potential]]></article-title>
<source><![CDATA[Trends Endocrinol Metab]]></source>
<year>2018</year>
<volume>29</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>723-35</page-range></nlm-citation>
</ref>
<ref id="B37">
<label>37</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dean]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Vilardaga]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
<name>
<surname><![CDATA[Potts Jr]]></surname>
<given-names><![CDATA[JT]]></given-names>
</name>
<name>
<surname><![CDATA[Gardella]]></surname>
<given-names><![CDATA[TJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor]]></article-title>
<source><![CDATA[Mol Endocrinol]]></source>
<year>2008</year>
<volume>22</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>156-66</page-range></nlm-citation>
</ref>
<ref id="B38">
<label>38</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vilardaga]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
<name>
<surname><![CDATA[Romero]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Krasel]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Seifert]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Gardella]]></surname>
<given-names><![CDATA[TJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Molecular mechanisms of PTH/PTHrP class B GPCR signaling and pharmacological implications]]></article-title>
<source><![CDATA[Endocr Rev]]></source>
<year>2023</year>
<volume>44</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>474-91</page-range></nlm-citation>
</ref>
<ref id="B39">
<label>39</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Okazaki]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ferrandon]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Vilardaga]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
<name>
<surname><![CDATA[Bouxsein]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
<name>
<surname><![CDATA[Potts Jr]]></surname>
<given-names><![CDATA[JT]]></given-names>
</name>
<name>
<surname><![CDATA[Gardella]]></surname>
<given-names><![CDATA[TJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation]]></article-title>
<source><![CDATA[Proc Natl Acad Sci U S A]]></source>
<year>2008</year>
<volume>105</volume>
<numero>44</numero>
<issue>44</issue>
<page-range>16525-30</page-range></nlm-citation>
</ref>
<ref id="B40">
<label>40</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ferrandon]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Feinstein]]></surname>
<given-names><![CDATA[TN]]></given-names>
</name>
<name>
<surname><![CDATA[Castro]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Bouley]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Potts]]></surname>
<given-names><![CDATA[JT]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sustained cyclic AMP production by parathyroid hormone receptor endocytosis]]></article-title>
<source><![CDATA[Nat Chem Biol]]></source>
<year>2009</year>
<volume>5</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>734-42</page-range></nlm-citation>
</ref>
<ref id="B41">
<label>41</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hattersley]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Dean]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Corbin]]></surname>
<given-names><![CDATA[BA]]></given-names>
</name>
<name>
<surname><![CDATA[Bahar]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Gardella]]></surname>
<given-names><![CDATA[TJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Binding selectivity of abaloparatide for PTH-type-1-receptor conformations and effects on downstream signaling]]></article-title>
<source><![CDATA[Endocrinology]]></source>
<year>2016</year>
<volume>157</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>141-9</page-range></nlm-citation>
</ref>
<ref id="B42">
<label>42</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Peña]]></surname>
<given-names><![CDATA[KA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Endosomal parathyroid hormone receptor signaling]]></article-title>
<source><![CDATA[Am J Physiol Cell Physiol]]></source>
<year>2022</year>
<volume>323</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>C783-90</page-range></nlm-citation>
</ref>
<ref id="B43">
<label>43</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Feinstein]]></surname>
<given-names><![CDATA[TN]]></given-names>
</name>
<name>
<surname><![CDATA[Wehbi]]></surname>
<given-names><![CDATA[VL]]></given-names>
</name>
<name>
<surname><![CDATA[Ardura]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Wheeler]]></surname>
<given-names><![CDATA[DS]]></given-names>
</name>
<name>
<surname><![CDATA[Ferrandon]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Gardella]]></surname>
<given-names><![CDATA[TJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Retromer terminates the generation of cAMP by internalized PTH receptors]]></article-title>
<source><![CDATA[Nat Chem Biol]]></source>
<year>2011</year>
<volume>7</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>278-84</page-range></nlm-citation>
</ref>
<ref id="B44">
<label>44</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Miller]]></surname>
<given-names><![CDATA[PD]]></given-names>
</name>
<name>
<surname><![CDATA[Hattersley]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Riis]]></surname>
<given-names><![CDATA[BJ]]></given-names>
</name>
<name>
<surname><![CDATA[Williams]]></surname>
<given-names><![CDATA[GC]]></given-names>
</name>
<name>
<surname><![CDATA[Lau]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Russo]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[ACTIVE Study Investigators. Effect of abaloparatide vs placebo on new vertebral fractures in postmenopausal women with osteoporosis:a randomized clinical trial]]></article-title>
<source><![CDATA[JAMA]]></source>
<year>2016</year>
<volume>316</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>722-33</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
