<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2254-2884</journal-id>
<journal-title><![CDATA[Enfermería Nefrológica]]></journal-title>
<abbrev-journal-title><![CDATA[Enferm Nefrol]]></abbrev-journal-title>
<issn>2254-2884</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Española de Enfermería Nefrológica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2254-28842018000100002</article-id>
<article-id pub-id-type="doi">10.4321/s2254-28842018000100002</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Dos métodos de anticoagulación en técnicas continuas de depuración extrarrenal]]></article-title>
<article-title xml:lang="en"><![CDATA[Two anticoagulation methods in continuous extra-renal depuration techniques]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aragó Sorrosal]]></surname>
<given-names><![CDATA[Sergi]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodas Marín]]></surname>
<given-names><![CDATA[Lida María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torres]]></surname>
<given-names><![CDATA[Ferrán]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villegas Jiménez]]></surname>
<given-names><![CDATA[Vanesa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Poch López de Briñas]]></surname>
<given-names><![CDATA[Esteban]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Clínic Instituto clínico de Nefrología y Urología Sección hemodiálisis]]></institution>
<addr-line><![CDATA[Barcelona ]]></addr-line>
<country>Spain</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Clínic Instituto clínico de Nefrología y Urología ]]></institution>
<addr-line><![CDATA[Barcelona ]]></addr-line>
<country>Spain</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS) Plataforma de bioestadística ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Spain</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital Clínic Instituto clínico de Nefrología y Urología ]]></institution>
<addr-line><![CDATA[Barcelona ]]></addr-line>
<country>Spain</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2018</year>
</pub-date>
<volume>21</volume>
<numero>1</numero>
<fpage>9</fpage>
<lpage>17</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S2254-28842018000100002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S2254-28842018000100002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S2254-28842018000100002&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción:  Las técnicas continuas de depuración extrarrenal son la terapia de elección en pacientes críticos. Pero, no están exentas de complicaciones como la coagulación del circuito extracorpóreo. El fármaco usado tradicionalmente para la anticoagulación, es la heparina sódica. Aunque también son empleados otros métodos de anticoagulación, como el citrato.  Objetivo:  Evaluar la eficacia y seguridad de dos métodos de anticoagulación en pacientes tratados con terapias continuas, en unidades de cuidados intensivos del Hospital Clínic.  Material y Método:  Estudio observacional, retrospectivo de 54 sujetos. Se aplicaron los criterios de Insuficiencia renal aguda, descritos en el protocolo "Guía para el tratamiento sustitutivo renal en la insuficiencia renal aguda del Hospital Clínic". Tratados mediante hemodiafiltración, combinando terapias de convección y difusión. Con fracción de filtración &lt; 25%, y dosis de efluente de 30 ml/kg/h. 27 sujetos realizaron hemodiafiltración, reposición pre-filtro y anticoagulación con heparina sódica. El resto, hemodiafiltración, reposición post-filtro y anticoagulación con citrato. Se valoraron episodios de sangrado y duración en horas de los circuitos extracorpóreos, durante 72 horas de terapia.  Resultados:  El citrato demostró una mayor supervivencia de filtros (95% IC, MD 65, 44.00-72.00 vs MD 36.00, 15.00-22.00, p=0,02). Los pacientes tratados con heparina presentaron más episodios de sangrado, sin diferencias estadísticamente significativas (95% IC, n=6 vs n=9, p=0.537). Hubo un episodio de hipocalcemia en el grupo citrato, corregido según protocolo. En el grupo heparina, no se presentaron casos de trombocitopenia inducida por heparina.  Conclusiones:  El presente estudio, demuestra una mayor eficacia en la supervivencia de los filtros en el grupo citrato.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction:  Continuous extra-renal depuration techniques are the therapy of choice in critically ill patients. But, they are not exempt from complications such as the coagulation of the extracorporeal circuit. The drug traditionally used for anticoagulation is sodium heparin. Although other methods of anticoagulation, such as citrate, are also used.  Objective:  To evaluate the efficacy and safety of two anticoagulation methods in patients treated with continuous therapies, in intensive care units of the Hospital Clinic of Barcelona.  Material and Method:  A retrospective observational study with 54 subjects was carried out. The criteria of acute renal insufficiency, described in the protocol "Guide for renal replacement therapy in acute renal failure at the Hospital Clínic" were applied. Patients were treated by hemodiafiltration, combining convection and diffusion therapies; with filtration fraction &lt; 25%, and effluent dose of 30ml/kg/h. Twenty-seven subjects performed hemodiafiltration, pre-filter replacement and anticoagulation with sodium heparin. The rest, hemodiafiltration, post-filter replacement and anticoagulation with citrate. Episodes of bleeding and duration in hours of the extracorporeal circuits were evaluated during 72 hours of therapy.  Results:  Citrate demonstrated a greater survival of filters (95% CI, MD 65, 44.00-72.00 vs. MD 36.00, 15.00-22.00, p=0.02). Patients treated with heparin had more episodes of bleeding, without statistically significant differences (95% CI, n=6 vs. n=9, p=0.537). There was an episode of hypocalcemia in the citrate group, corrected according to protocol. In the heparin group, there were no cases of heparin-induced thrombocytopenia.  Conclusions: The present study demonstrates greater efficacy in the survival of filters in the citrate group.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[citrato]]></kwd>
<kwd lng="es"><![CDATA[heparina]]></kwd>
<kwd lng="es"><![CDATA[anticoagulación regional]]></kwd>
<kwd lng="es"><![CDATA[terapia continua depuración extrarrenal]]></kwd>
<kwd lng="es"><![CDATA[fracaso renal agudo]]></kwd>
<kwd lng="en"><![CDATA[citrate]]></kwd>
<kwd lng="en"><![CDATA[heparin]]></kwd>
<kwd lng="en"><![CDATA[regional anticoagulation]]></kwd>
<kwd lng="en"><![CDATA[Continuous therapy]]></kwd>
<kwd lng="en"><![CDATA[Extra-renal depuration]]></kwd>
<kwd lng="en"><![CDATA[Acute renal failure]]></kwd>
</kwd-group>
</article-meta>
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