<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2340-9894</journal-id>
<journal-title><![CDATA[Ars Pharmaceutica (Internet)]]></journal-title>
<abbrev-journal-title><![CDATA[Ars Pharm]]></abbrev-journal-title>
<issn>2340-9894</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Granada]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2340-98942017000200003</article-id>
<article-id pub-id-type="doi">10.30827/ars.v58i2.6380</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Comparison of three independent methods of cephalexin determination by means of potassium caroate]]></article-title>
<article-title xml:lang="es"><![CDATA[Comparación de tres métodos independientes para la detección de cefalexina usando el potasio de caroata]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Blazheyevskiy Mykola]]></surname>
<given-names><![CDATA[Ye]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Serdiukova Yuliia]]></surname>
<given-names><![CDATA[Yu]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,National University of Pharmacy Department of Physical and Colloid Chemistry ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<volume>58</volume>
<numero>2</numero>
<fpage>59</fpage>
<lpage>65</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S2340-98942017000200003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S2340-98942017000200003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S2340-98942017000200003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Aims: Three different assays for the quantity determination of Cephalexin in pure substance were developed and compared using potassium caroate as analytical reagent.  Materials and Methods: Cephalexin pure substance was used and analytical reaction by means of KHSO5 as an oxidant was studied. Voltammetric, kinetic-spectrophotometric and iodometric methods were developed and validated.  Results: The chemical reaction is finished with formation of the S-oxide of Cephalexin in the iodometric and voltammetric methods and the S-oxide hydrolysis product in the kinetic-spectrophotometric method. The reaction finishes in 1 min (observation time). The methods have been validated and good results including precision, accuracy and recovery were obtained. The recovery percent ranged from 98.7 to 101.4%, RSD from 1.42 to 3.0%. The methods proposed are linear in a wide range: voltammetry 2-45 &#956;g mL-1, kinetic-spectrophotometry 1-16 &#956;g mL-1, and iodometry 0.05-0.35 mg mL-1. LOD and LOQ were calculated. The kinetic-spectrophotometric method is the most sensitive (LOQ=1.0 &#956;g mL-1).  Conclusions: The methods proposed are rapid, simple and inexpensive and could be applied to pharmaceutical preparation.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Objetivo: Se han desarrollado tres métodos diferentes para la detección cuantitativa de Cefalexina en producto puro, usando el caroata de potasio como un reactivo analítico.  Materiales y métodos: Fue estudiada la reacción analítica de cefalexina con KHSO5 como oxidante. Se han desarrollado y validado los métodos de voltamperimetría, de espectrofotometría cinética y de iodometría.  Resultados: La reacción química se completa con la formación de s-óxido de Cefalexina dentro de los métodos de iodometría y de voltamperometría, y con la formación del producto de hidrólisis de s-óxido en el método de espectrofotometría cinética. La reacción se completa en 1 minuto (tiempo de observación). Los métodos han sido validados, y se han obtenido resultados buenos, incluida la exactitud, la fiabilidad y la reproducibilidad. El contenido de la sustancia básica oscila desde 98,7% hasta 101,4%. El RSD está entre 1,42 y 3,0%. Los métodos propuestos son lineales en un amplio espectro: la voltamperometría 2-45 &#956;g ml-1, la espectrofotometría cinética 1-16 &#956;g ml-1, y la iodometría 0,05-0,35 mg ml-1. Han sido calculados el límite de detección y el límite de cuantificación. El método de espectrofotometría cinética es el más sensible (el límite de cuantificación = 1,0 mcg ml-1).  Conclusiones: Los métodos propuestos son rápidos, simples y baratos, y pueden ser utilizados en las preparaciones farmacéuticas.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Cephalexin]]></kwd>
<kwd lng="en"><![CDATA[iodometry]]></kwd>
<kwd lng="en"><![CDATA[kinetic-spectrophotometry]]></kwd>
<kwd lng="en"><![CDATA[potassium caroate]]></kwd>
<kwd lng="en"><![CDATA[voltammetry]]></kwd>
<kwd lng="es"><![CDATA[Cefalexina]]></kwd>
<kwd lng="es"><![CDATA[iodometría]]></kwd>
<kwd lng="es"><![CDATA[voltamperometría]]></kwd>
<kwd lng="es"><![CDATA[caroata de potasio]]></kwd>
<kwd lng="es"><![CDATA[espectrofotometría cinética]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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