<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2340-9894</journal-id>
<journal-title><![CDATA[Ars Pharmaceutica (Internet)]]></journal-title>
<abbrev-journal-title><![CDATA[Ars Pharm]]></abbrev-journal-title>
<issn>2340-9894</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Granada]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2340-98942019000500004</article-id>
<article-id pub-id-type="doi">10.30827/ars.v60i3.9289</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Performance evaluation of maize starch as a multifunctional excipient in metronidazole tablet formulation]]></article-title>
<article-title xml:lang="es"><![CDATA[Evaluación del rendimiento del almidón de maíz como excipiente multifuncional en la formulación de comprimidos de metronidazol]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Apeji]]></surname>
<given-names><![CDATA[Yonni Eshovo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Abdulhakim]]></surname>
<given-names><![CDATA[Ali]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Anyebe]]></surname>
<given-names><![CDATA[Sophie Nock]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Orugun]]></surname>
<given-names><![CDATA[Oluwaseun Adenike]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Olowosulu]]></surname>
<given-names><![CDATA[Adeniji Kehinde]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Oyi]]></surname>
<given-names><![CDATA[Avosuahi Rukayat]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Ahmadu Bello University Faculty of Pharmaceutical Sciences ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Nigeria</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Kaduna State University Faculty of Pharmaceutical Sciences ]]></institution>
<addr-line><![CDATA[ Kaduna State]]></addr-line>
<country>Nigeria</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2019</year>
</pub-date>
<volume>60</volume>
<numero>3</numero>
<fpage>161</fpage>
<lpage>167</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S2340-98942019000500004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S2340-98942019000500004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S2340-98942019000500004&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Objective: The aim of this study was to evaluate the performance of maize starch as a multifunctional excipient in metronidazole tablet formulation.  Methods: Metronidazole tablets were prepared by wet granulation containing maize starch as diluent (40 %), disintegrant (10 %), and binder (5 %) and compared with a reference formulation containing lactose as diluent (40 %), maize starch as disintegrant (10 %) and acacia as binder (5 %). The granules were analysed for particle size, flow properties, compressibility and moisture content. Tablets weighing 500 mg were compressed for both formulations on a Single Punch Tablet Press using a 12 mm flat-faced punches at 57.5 MPa. The tablets were kept for 24 h to allow for elastic recovery and evaluated for weight and content uniformity, thickness, crushing strength, friability, disintegration time and in vitro drug release.  Results: The granule properties revealed differences in mean granule size, angle of repose, bulk and tapped densities for both formulations. Batch I tablets gave rise to better tableting properties compared to batch II tablets.  Conclusion: This study confirms the suitability of maize starch as a multifunctional excipient in tablet formulation.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Objetivo: El objetivo de este estudio fue evaluar el rendimiento del almidón de maíz como excipiente multifuncional en la formulación de comprimidos de metronidazol.  Métodos: Metronidazol Tabletas En Honorario preparado por granulación húmeda que contiene almidón de maíz como diluyente (40%), desintegrante (10%) y aglutinante (5%) y en comparación con una formulación de referencia que contiene lactosa como diluyente (40%), almidón de maíz como desintegrante (10%) y Acacia como aglutinante (5%). Los gránulos se analizaron para el tamaño de partícula, propiedades de flujo, compresibilidad y contenido de humedad. Las tabletas con un peso de 500 mg fueron comprimidas para ambas formulaciones en una simple Punch Tablet Press usando un punzón de 12 mm de cara plana en 57,5 MPa. Los comprimidos se mantuvieron durante 24 h para permitir la recuperación elástica y evaluar el peso y el contenido uniformidad, espesor, resistencia a la trituración, friabilidad, tiempo de desintegración y in vitro liberación de drogas.  Resultados: Las propiedades del gránulo revelaron diferencias en el tamaño medio del gránulo, el ángulo de reposo, las densidades a granel y roscado para ambas formulaciones. Los comprimidos de Batch I dieron lugar a mejores propiedades de comprimidos en comparación con los comprimidos de lote II.  Conclusión: Este estudio confirma la idoneidad del almidón de maíz como excipiente multifuncional en la formulación de comprimidos.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Maize starch]]></kwd>
<kwd lng="en"><![CDATA[multifunctional excipient]]></kwd>
<kwd lng="en"><![CDATA[granules]]></kwd>
<kwd lng="en"><![CDATA[tableting]]></kwd>
<kwd lng="es"><![CDATA[Almidón de maíz]]></kwd>
<kwd lng="es"><![CDATA[excipiente multifuncional]]></kwd>
<kwd lng="es"><![CDATA[gránulos]]></kwd>
<kwd lng="es"><![CDATA[comprimides]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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