<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2340-9894</journal-id>
<journal-title><![CDATA[Ars Pharmaceutica (Internet)]]></journal-title>
<abbrev-journal-title><![CDATA[Ars Pharm]]></abbrev-journal-title>
<issn>2340-9894</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Granada]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2340-98942019000500005</article-id>
<article-id pub-id-type="doi">10.30827/ars.v60i3.9219</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Evaluación antimicrobiana de un extracto metanólico de Beauveria bassiana contra bacterias patógenas de importancia nosocomial]]></article-title>
<article-title xml:lang="en"><![CDATA[Antimicrobial evaluation of a methanol extract of Beauveria bassiana against pathogenic bacteria of nosocomial importance]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villegas-Mendoza]]></surname>
<given-names><![CDATA[Jesús M]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rosas-García]]></surname>
<given-names><![CDATA[Ninfa M]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mireles-Martínez]]></surname>
<given-names><![CDATA[Maribel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santiago-Adame]]></surname>
<given-names><![CDATA[Rubén]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Castillejos]]></surname>
<given-names><![CDATA[Guadalupe C]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Camacho-Corona]]></surname>
<given-names><![CDATA[M del Rayo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morales-San Claudio]]></surname>
<given-names><![CDATA[Pilar del C]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Politécnico Nacional Centro de Biotecnología Genómica Laboratorio de Biotecnología Ambiental]]></institution>
<addr-line><![CDATA[Reynosa Tamps]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Autónoma de Tamaulipas Unidad Académica Multidisciplinaria Reynosa-Aztlán ]]></institution>
<addr-line><![CDATA[Reynosa Tamps]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Autónoma de Nuevo León Facultad de Ciencias Químicas ]]></institution>
<addr-line><![CDATA[San Nicolás de los Garza Nuevo León]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2019</year>
</pub-date>
<volume>60</volume>
<numero>3</numero>
<fpage>169</fpage>
<lpage>176</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S2340-98942019000500005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S2340-98942019000500005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S2340-98942019000500005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Objetivo: Se evaluó la actividad antimicrobiana de un extracto crudo de B. bassiana y dos fracciones del mismo contra bacterias de importancia clínica.  Métodos: El micelio de cepa B. bassiana se remojó en metanol durante una semana, después se evaporo en un rotovapor a 45°C aplicando vacío. El extracto metanólico se hizo pasar con dos fases móviles para obtener una fracción A y B. La fracciones A, B y el extracto crudo C se evaluaron contra las cepas Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Salmonella tiphy, Pseudomonas aeruginosa y Acinetobacter baumannii con la técnica de microdilución en placa.  Resultados: En la fracción A se observó un efecto antimicrobiano contra Salmonella typhi, Pseudomonas aeruginosa y Acinetobacter baumannii el crecimiento bacteriano alcanzó el 70, 60 y 83 % respectivamente. La fracción B causó un efecto antimicrobiano en Klebsiella pneumoniae, S. typhi, P. aeruginosa y A. baumannii con un crecimiento bacteriano del 62, 58, 41 y 7 % respectivamente. Y El extracto crudo no causó inhibición del crecimiento en A. baumannii, pero para el resto de la bacterias hubo un crecimiento del 56 al 88 %.  Conclusiones: Beauveria bassiana es un hongo entomopatógeno que produce diferentes metabolitos con actividad insecticida, citotóxica, antifúngica, antibiótica y antiviral. Este es el primer estudio de los efectos antimicrobianos de un extracto metanólico del hongo entomopatógeno B. bassiana contra cepas bacterianas de importancia clínica.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Objective: The antimicrobial activity of a crude extract of B. bassiana and two fractions thereof against clinically important bacteria was evaluated.  Methods: The mycelium of strain B. bassiana was soaked in methanol for a week, then it was evaporated in a rotovap at 45 ° C applying a vacuum. The methanolic extract was passed through two mobile phases to obtain a fraction A and B. Fractions A, B and crude extract C were evaluated against the strains Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Salmonella tiphy, Pseudomonas aeruginosa and Acinetobacter baumannii with the plate microdilution technique.  Results: In fraction A an antimicrobial effect against Salmonella typhi, Pseudomonas aeruginosa and Acinetobacter baumannii was observed, bacterial growth reached 70, 60 and 83% respectively. Fraction B caused an antimicrobial effect in Klebsiella pneumoniae, S. typhi, P. aeruginosa and A. baumannii with a bacterial growth of 62, 58, 41 and 7% respectively. And the crude extract did not cause growth inhibition in A. baumannii, but for the rest of the bacteria there was a growth of 56 to 88%.  Conclusions: Beauveria bassiana is an entomopathogenic fungus that produces different metabolites with insecticidal, cytotoxic, antifungal, antibiotic and antiviral activity. This is the first study of the antimicrobial effects of a methanolic extract of the entomopathogenic fungus B. bassiana against bacterial strains of clinical importance.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Bacterias patógenas]]></kwd>
<kwd lng="es"><![CDATA[Beauveria bassiana]]></kwd>
<kwd lng="es"><![CDATA[Antimicrobial]]></kwd>
<kwd lng="en"><![CDATA[Pathogenic bacteria]]></kwd>
<kwd lng="en"><![CDATA[Beauveria bassiana]]></kwd>
<kwd lng="en"><![CDATA[Antimicrobial]]></kwd>
</kwd-group>
</article-meta>
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