<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2340-9894</journal-id>
<journal-title><![CDATA[Ars Pharmaceutica (Internet)]]></journal-title>
<abbrev-journal-title><![CDATA[Ars Pharm]]></abbrev-journal-title>
<issn>2340-9894</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Granada]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2340-98942020000400005</article-id>
<article-id pub-id-type="doi">10.30827/ars.v61i4.15352</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[In vivo anti-inflammatory effect of saponin-enriched fraction from Agave brittoniana Trel subspecie brachypus]]></article-title>
<article-title xml:lang="es"><![CDATA[Efecto antiinflamatorio in vivo de fracción enriquecida de saponinas de Agave brittoniana Trel subespecie brachypus]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González-Madariaga]]></surname>
<given-names><![CDATA[Yisel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mena-Linares]]></surname>
<given-names><![CDATA[Yilka]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martín-Monteagudo]]></surname>
<given-names><![CDATA[Dalys]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valido-Díaz]]></surname>
<given-names><![CDATA[Arianna]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guerra-de-León]]></surname>
<given-names><![CDATA[José Orestes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Nieto-Reyes]]></surname>
<given-names><![CDATA[Leisy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Villa Clara Unidad de Toxicología Experimental ]]></institution>
<addr-line><![CDATA[Santa Clara VC]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Central &#8220;Marta Abreu&#8221; de las Villas Facultad de Química-Farmacia Departamento de Farmacia]]></institution>
<addr-line><![CDATA[Santa Clara VC]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Central &#8220;Marta Abreu&#8221; de las Villas Facultad de Química-Farmacia Departamento de Química]]></institution>
<addr-line><![CDATA[Santa Clara VC]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<volume>61</volume>
<numero>4</numero>
<fpage>231</fpage>
<lpage>237</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S2340-98942020000400005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S2340-98942020000400005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S2340-98942020000400005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: Agave brittoniana Trel species. subsp. brachypus is characterized by its high content of steroidal saponins and these metabolites have anti-inflammatory properties. However, no previous studies indicate that extracts rich in saponins from this species have anti-inflammatory effect in vivo models.  Method: Steroidal saponins in n-butanolic extract were obtained from a hydroalcoholic extract of Agave brittoniana. Phytochemical studies were used to verify the saponins presence. Doses of 25, 50 and 100 mg/kg were used in the acute model of edema induced by carrageenan and in the chronic model of cotton pellet-induced granuloma. Five groups of six male Sprague-Dawley rats each were designed by each in vivo study: three groups for saponin-enriched fraction at different doses, a normal control group and a positive control, which was treated with indomethacin. The inhibition percentage of the inflammatory reaction was the major answer variable.  Results: The acute model of carrageenan-induced rat paw edema indicated that the groups corresponding to the doses of 50 and 100 mg/kg of saponin-enriched fraction showed the highest percentages of inhibition, after three hours of treatment. According to the chronic model results, saponins-enriched butanolic extract showed anti-inflammatory activity by reducing the dry weight of the granuloma and increasing the inhibition percentage.  Conclusions: Saponin-enriched fraction from Agave brittoniana T. subsp. brachypus, have an anti-inflammatory effect in acute and chronic experimental models.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: La especie Agave brittoniana Trel. subsp. brachypus se caracteriza por su alto contenido de saponinas esteroidales y estos metabolitos presentan propiedades antiinflamatorias. Sin embargo, ningún estudio previo señala que extractos ricos en saponinas de esta especie tienen efecto antiinflamatorio en modelos in vivo.  Método: Saponinas esteroidales extraídas en n-butanólico fueron obtenidas a partir de un extracto hidroalcohólico de Agave brittoniana. Estudios fitoquímicos se usaron para corroborar la presencia de saponinas. Dosis de 25, 50 y 100 mg/kg fueron usadas en el modelo agudo de edema inducido por carragenina y en el modelo crónico de granuloma inducido por pellet de algodón. Se diseñaron cinco grupos de seis ratas machos Sprague-Dawley cada uno: tres grupos para la fracción enriquecida de saponinas a las diferentes dosis, un grupo control normal y un control positivo, el cual fue tratado con indometacina. El porcentaje de inhibición de la reacción inflamatoria fue la principal variable respuesta.  Resultados: El modelo agudo de edema plantar inducido por carragenina reveló que las dosis de 50 y 100 mg/kg de la fracción enriquecida de saponinas mostraron los mayores porcentajes de inhibición, después de tres horas de tratamiento. Según los resultados del modelo crónico, el extracto butanólico enriquecido con saponinas mostró actividad antiinflamatoria por reducción del peso seco del granuloma e incremento del porcentaje de inhibición.  Conclusiones: La fracción enriquecida de saponinas de Agave brittoniana T. subsp. brachypus, tiene un efecto antiinflammatorio en modelos experimentales agudo y crónico.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[saponins]]></kwd>
<kwd lng="en"><![CDATA[Agave]]></kwd>
<kwd lng="en"><![CDATA[anti-inflammatory]]></kwd>
<kwd lng="en"><![CDATA[carrageenan]]></kwd>
<kwd lng="en"><![CDATA[granuloma]]></kwd>
<kwd lng="es"><![CDATA[saponinas]]></kwd>
<kwd lng="es"><![CDATA[Agave]]></kwd>
<kwd lng="es"><![CDATA[antiinflamatorio]]></kwd>
<kwd lng="es"><![CDATA[carragenina]]></kwd>
<kwd lng="es"><![CDATA[granuloma]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Calderón]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Karina]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Recio]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Revisión de las bases flsiopatológicas de la inflamación]]></article-title>
<source><![CDATA[Revista CONAMED]]></source>
<year>2017</year>
<volume>22</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>48-51</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Castilla]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Lorenzo]]></surname>
<given-names><![CDATA[A de]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Respuesta inflamatoria sistemàtica: fisiopatologia y mediadores]]></article-title>
<source><![CDATA[Medicina Intensiva]]></source>
<year>2000</year>
<volume>24</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>353-60</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jiménez]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Debesa]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Bastanzuri]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Ávila]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comportamiento de las reacciones adversas a los analgésicos y antiinflamatorios no esteroideos notificadas por el Sistema Cubano de Farmacovigilancia en el 2001]]></article-title>
<source><![CDATA[Rev Cubana Farm]]></source>
<year>2003</year>
<volume>37</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>1</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aravinthan]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Antonisamy]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Kang]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Choi]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ginseng total saponin attenuates myocardial injury via anti-oxidative and anti-inflammatory properties]]></article-title>
<source><![CDATA[J Ginseng Res]]></source>
<year>2015</year>
<volume>39</volume>
<page-range>206-12</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ramalingam]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pharmacological Activities and Applications of Spicatoside A]]></article-title>
<source><![CDATA[Biomol Ther]]></source>
<year>2016</year>
<volume>24</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>469-74</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mohammed]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Osman]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Garelnabi]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Osman]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Osman]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Khalid]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Secondary metabolites as anti-inflammatory agents]]></article-title>
<source><![CDATA[Phytopharm]]></source>
<year>2014</year>
<volume>3</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>275-85</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lande]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ambavade]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Swami]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
<name>
<surname><![CDATA[Adkar]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Ambavade]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Waghamare]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Saponins isolated from roots of Chlorophytumborivilianum reduce acute and chronic inflammation and histone deacetylase]]></article-title>
<source><![CDATA[J Integr Med]]></source>
<year>2015</year>
<volume>13</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>25-33</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Greuter]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Rankin-Rodríguez]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Plantas Vasculares de Cuba. Inventario preliminar]]></article-title>
<source><![CDATA[Espermatófitos de Cuba con inclusión de los Pteridófitos: Botanischer Garten &amp; Botanisches Museum Berlin]]></source>
<year>2017</year>
<edition>Segunda</edition>
<publisher-loc><![CDATA[Jardín Botánico Nacional ]]></publisher-loc>
<publisher-name><![CDATA[Universidad de La Habana]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Monterrosas-Brisson]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Arenas]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Jiménez-Ferrer]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Jiménez-Aparicio]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Zamilpa]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Gonzalez-Cortazar]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Anti-Inflammatory activity of different Agave plants and the compound cantalasaponin-1]]></article-title>
<source><![CDATA[Molecules]]></source>
<year>2013</year>
<volume>18</volume>
<page-range>8136-46</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dunder]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Quaglio]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Maciel]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Luiz-Ferreira]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Almeida]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Takayama]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antiinflammatory and analgesic potential of hydrolyzed extract of Agave sisalana Perrine ex Engelm., Asparagaceae]]></article-title>
<source><![CDATA[Rev Bras Farmacogn]]></source>
<year>2010</year>
<volume>20</volume>
<page-range>376-81</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hernández-Valle]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Herrera-Ruiz]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Rosas]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Zamilpa]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Arenas]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Jiménez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Anti-Inflammatory effect of 3-O-[(6'-O-palmitoyl)-ß-Dglucopyranosyl sitosterol] from Agave angustifolia on ear edema in mice]]></article-title>
<source><![CDATA[Molecules]]></source>
<year>2014</year>
<volume>19</volume>
<page-range>15624-37</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[B da]]></given-names>
</name>
<name>
<surname><![CDATA[Parente]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A New Bioactive Steroidal Saponin from Agave brittoniana]]></article-title>
<source><![CDATA[Z Naturforsch]]></source>
<year>2007</year>
<volume>62b</volume>
<page-range>1193-8</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Macías]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Guerra]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Simonet]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Nogueiras]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Characterization of the fraction components using 1D TOCSY and 1D ROESY experiments. Four new spirostane saponins from Agave brittoniana Trel. Spp. Brachypus]]></article-title>
<source><![CDATA[Magn Reson Chem]]></source>
<year>2007</year>
<volume>45</volume>
<page-range>615-20</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Norma Ramal de Salud Pública 309. Métodos de Ensayo de Droga cruda]]></article-title>
<source><![CDATA[MINSAP]]></source>
<year>1991</year>
<page-range>30-40</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guerra]]></surname>
<given-names><![CDATA[JO]]></given-names>
</name>
</person-group>
<source><![CDATA[Compuestos con actividad antiparasitaria, del "Agave brittoniana T'']]></source>
<year>2005</year>
<publisher-name><![CDATA[Universidad de Cádiz. Universidad de La Habana. Universidad Central "Marta Abreu" de Las Villas]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guerra]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Meneses]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Simonet]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Macías]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Nogueiras]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Gómez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Saponinas esteroidales de la planta Agave brittoniana (Agavaceae) con actividad contra el parásito Trichomona vaginalis]]></article-title>
<source><![CDATA[Rev Biol Trop]]></source>
<year>2008</year>
<volume>56</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>1645-52</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Macías]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Guerra]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Simonet]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Nogueiras]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Characterization of three saponins from a fraction using 1D DOSY as a solvent signal suppression tool Agabrittonosides E-F. Furostane Saponins from Agave brittoniana Trel. spp. brachypus]]></article-title>
<source><![CDATA[Magn Reson Chem]]></source>
<year>2010</year>
<volume>48</volume>
<page-range>350-5</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Miranda]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Cuéllar]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Farmacognosia y Productos Naturales]]></source>
<year>2001</year>
<edition>2a</edition>
<publisher-loc><![CDATA[La Habana ]]></publisher-loc>
<publisher-name><![CDATA[Editorial Félix Varela]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="book">
<collab>CYTED</collab>
<source><![CDATA[Manual de técnicas de investigación. Proyecto X-I. Búsqueda de principios bioactivos en Plantas de la Región. Subprograma X. Química Fina Farmacéutica]]></source>
<year>1995</year>
<page-range>81-98</page-range><publisher-name><![CDATA[Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mahat]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Patil]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluation of antiinflammatory activity of methanol extract of Phyllanthus amarus in experimental animal models]]></article-title>
<source><![CDATA[Indian J Pharm Sci]]></source>
<year>2007</year>
<volume>69</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>33-6</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sanmugapriya]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Shanmugasundara]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Venkataraman]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Anti-inflammatory activity of Justicia prostrata Gamble in acute and sub-acute models of inflammation]]></article-title>
<source><![CDATA[Inflammopharmacology]]></source>
<year>2005</year>
<volume>13</volume>
<numero>5-6</numero>
<issue>5-6</issue>
<page-range>493-500</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="book">
<collab>National Institutes of Health</collab>
<source><![CDATA[Principles of laboratory animal care]]></source>
<year>1985</year>
<page-range>85-23</page-range><publisher-name><![CDATA[NIH publication]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Quillay Davila]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Arana Arias]]></surname>
<given-names><![CDATA[YAA]]></given-names>
</name>
<name>
<surname><![CDATA[Jaramillo Jaramillo]]></surname>
<given-names><![CDATA[CG]]></given-names>
</name>
<name>
<surname><![CDATA[Cuenca Buele]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Rojas de Astudillo]]></surname>
<given-names><![CDATA[LL]]></given-names>
</name>
<name>
<surname><![CDATA[Jaramillo Alcívar]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Contenido de saponinas y actividad cicatrizante de Cecropia peltata y Parthenium hysterophorus]]></article-title>
<source><![CDATA[Rev Cubana Farm]]></source>
<year>2018</year>
<volume>51</volume>
<numero>3</numero>
<issue>3</issue>
</nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Galindo]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Luiz Abdalla]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Alberto]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Lucas]]></surname>
<given-names><![CDATA[RC]]></given-names>
</name>
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[KC Dos]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effect of a raw saponin extract on ruminal microbial population and in vitro methane production with star grass (Cynodon nlemfuensis) substrate]]></article-title>
<source><![CDATA[Rev Cubana Ciencia Agrícola]]></source>
<year>2016</year>
<volume>50</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>77-88</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tenon]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Feuillère]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Roller]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Birtic]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Rapid, cost-effective and accurate quantification of Yucca schidigera Roezl. steroidal saponins using HPLC-ELSD method]]></article-title>
<source><![CDATA[Food Chem]]></source>
<year>2017</year>
<volume>221</volume>
<page-range>1245-52</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Adcock]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Ito]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Molecular mechanisms of corticosteroid actions]]></article-title>
<source><![CDATA[Monaldi Arch Chest Dis]]></source>
<year>2000</year>
<volume>55</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>256-66</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ramamoorthy]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Cidlowski]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Corticosteroids: mechanisms of action in health and disease]]></article-title>
<source><![CDATA[Rheumatic Disease Clinics]]></source>
<year>2016</year>
<volume>42</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>15-31</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sugishita]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Amagaya]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Ogihara]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Anti-inflammatory testing methods: comparative evaluation of mice and rats]]></article-title>
<source><![CDATA[J Pharmaco-Biodyn]]></source>
<year>1981</year>
<volume>4</volume>
<page-range>565-75</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mansouri]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Hemmati]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Naghizadeh]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Mard]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Rezaie]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ghorbanzadeh]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A study of the mechanisms underlying the anti-inflammatory effect of ellagic acid in carrageenan-induced paw edema in rats]]></article-title>
<source><![CDATA[Indian J Pharmacol]]></source>
<year>2015</year>
<volume>47</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>292</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sandhya]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Venkatramana]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Vinod]]></surname>
<given-names><![CDATA[KR]]></given-names>
</name>
<name>
<surname><![CDATA[Chaitanya]]></surname>
<given-names><![CDATA[RK]]></given-names>
</name>
<name>
<surname><![CDATA[Chandrasekhar]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Sudhakar]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Membrane stabilizing potency of two Tephrosia species]]></article-title>
<source><![CDATA[J Phytol]]></source>
<year>2010</year>
<volume>2</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>42-6</page-range></nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Böttger]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Hofmann]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Melzig]]></surname>
<given-names><![CDATA[MF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Saponins can perturb biologic membranes and reduce the surface tension of aqueous solutions: a correlation?]]></article-title>
<source><![CDATA[Bioorg Med Chem Lett]]></source>
<year>2012</year>
<volume>20</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>2822-8</page-range></nlm-citation>
</ref>
<ref id="B32">
<label>32</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ortiz]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Cariño-Cortés]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Ponce-Monter]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[González-García]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Castañeda-Hernández]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Salinas-Caballero]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Synergistic interaction of Matricaria chamomilla extract with diclofenac and indomethacin on carrageenan-induced paw inflammation in rats]]></article-title>
<source><![CDATA[Drug Development Research]]></source>
<year>2017</year>
<volume>78</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>360-7</page-range></nlm-citation>
</ref>
<ref id="B33">
<label>33</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Batista]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Trindade]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Lira]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Muller]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Batista]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antinociceptive and anti-inflammatory activities of Luehea divaricate ethanol extract]]></article-title>
<source><![CDATA[Rev Bras Plantas Med]]></source>
<year>2016</year>
<volume>18</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>433-41</page-range></nlm-citation>
</ref>
<ref id="B34">
<label>34</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Xu]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Cheng]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Cao]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Hang]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Zhou]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Anti-inflammatory effect of external use of escin on cutaneous inflammation: possible involvement of glucocorticoids receptor]]></article-title>
<source><![CDATA[Chin J Nat Med]]></source>
<year>2018</year>
<volume>16</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>105-12</page-range></nlm-citation>
</ref>
<ref id="B35">
<label>35</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Anti-inflammatory effect of an extract of Agave americana on experimental animals]]></article-title>
<source><![CDATA[Pharmacognosy Res]]></source>
<year>2018</year>
<volume>10</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>104-8</page-range></nlm-citation>
</ref>
<ref id="B36">
<label>36</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jung]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Byun]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diosgenin inhibits macrophage-derived inflammatory mediators through down regulation of CK2, JNK, NF-KB and AP-1 activation]]></article-title>
<source><![CDATA[Int Immunopharmacol]]></source>
<year>2010</year>
<volume>10</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1047-54</page-range></nlm-citation>
</ref>
<ref id="B37">
<label>37</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hierro]]></surname>
<given-names><![CDATA[J del]]></given-names>
</name>
<name>
<surname><![CDATA[Herrera]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Fornari]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Reglero]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Martin]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The gastrointestinal behavior of saponins and its significance for their bioavailability and bioactivities]]></article-title>
<source><![CDATA[J Funct Foods]]></source>
<year>2018</year>
<volume>40</volume>
<page-range>484-97</page-range></nlm-citation>
</ref>
<ref id="B38">
<label>38</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nodarse]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Castellanos]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Becerra]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Eficacia de los jugos de Furcraea hexapétala y Agave brittoniana para el control de moluscos plagas en acelga en organopónicos]]></article-title>
<source><![CDATA[Revista Científica Agroecosistemas]]></source>
<year>2015</year>
<volume>3</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>488-93</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
