2340-9894 2340-9894 S2340-98942020000400007 10.30827/ars.v61i4.15204 Perú Perú Brasil 00 12 2020 00 12 2020 61 4 245 252

1 2017 2 FDA - Food and Drug Administration 1997 3 FDA - Food and Drug Administration U.S. 2016 4 1995 12 1 1 413-20 5 2017 8 7 7 3133-7 6 2015 1-37 7 2017 17 28 28 119-31 8 1995 12 3 3 413-20 9 2010 10 2014 64 11 11 37-43 11 2016 509 2 2 35-40 12 2018 3 1 1 197-201 13 2016 1 3 3 14-24 14 2019 15 2010 1 1 1 15 16 World Health Organization 2006 17 2012 103-9 18 2011 3 27-9 19 1988 77 8 8 715-8 20 2019 73 12 12 1103-12 21 2019 53 1773-2247