<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2340-9894</journal-id>
<journal-title><![CDATA[Ars Pharmaceutica (Internet)]]></journal-title>
<abbrev-journal-title><![CDATA[Ars Pharm]]></abbrev-journal-title>
<issn>2340-9894</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Granada]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2340-98942022000100045</article-id>
<article-id pub-id-type="doi">10.30827/ars.v63i1.22507</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Estudio comparativo de la calidad biofarmacéutica de Diazepam 10 mg comercializados en el mercado peruano]]></article-title>
<article-title xml:lang="en"><![CDATA[Comparative study of the biopharmaceutical quality of Diazepam 10 mg commercialized in the Peruvian market]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Saavedra-Suárez]]></surname>
<given-names><![CDATA[Segundo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alva-Plasencia]]></surname>
<given-names><![CDATA[Pedro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gutiérrez-Ramos]]></surname>
<given-names><![CDATA[Miriam]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Curo-Vallejos]]></surname>
<given-names><![CDATA[Yuri]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodriguez-Saavedra]]></surname>
<given-names><![CDATA[Lennin]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Trujillo Facultad de Farmacia y Bioquímica ]]></institution>
<addr-line><![CDATA[Trujillo ]]></addr-line>
<country>Perú</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Chile Facultad de Ciencias Químicas y Farmacéuticas ]]></institution>
<addr-line><![CDATA[Santiago ]]></addr-line>
<country>Chile</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Nacional Mayor de San Marcos Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Lima ]]></addr-line>
<country>Perú</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<volume>63</volume>
<numero>1</numero>
<fpage>45</fpage>
<lpage>55</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S2340-98942022000100045&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S2340-98942022000100045&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S2340-98942022000100045&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción:  el Diazepam pertenece a un grupo de medicamentos llamados benzodiazepinas. Se sabe que estos medicamentos actúan en el cerebro a través del GABA. Se utiliza para aliviar la ansiedad y control de la agitación causada por la abstinencia de alcohol.  Método:  se evaluó la variación de peso, friabilidad, dureza, tiempo de desintegración, cuantificación de principio activo, velocidad y perfil de disolución entre el medicamento innovador y medicamentos multifuentes comercializados en el mercado peruano, según lo establecido en la USP 42.  Resultados:  los resultados permitieron establecer que todas las tabletas multifuente de Diazepam 10 mg incluidos en esta investigación son bioequivalentes con la marca innovadora elegida y, por lo tanto, pueden ser intercambiables.  Conclusiones:  se estableció que las tabletas multifuentes de Diazepam 10 mg incluidos en esta investigación son bioequivalentes con el innovador y, por lo que permite proponer a la comunidad científica la determinación de la equivalencia farmacéutica como elemento de apoyo en la toma de decisiones de compra en el servicio farmacéutico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction:  diazepam belongs to a group of medicines called benzodiazepines. These drugs are known to work in the brain through GABA and, it used to relieve anxiety and control the agitation caused by alcohol withdrawal.  Method:  variation in weight, friability, hardness, disintegration time, quantification of active ingredient, speed and dissolution profile between the innovative and multi-source drugs marketed in the Peruvian market. The evaluation of these presentations did with the USP 42 Pharmacopeia.  Results:  the results established that all Diazepam 10 mg multi-source tablets included in this research are bioequivalent with the chosen innovative brand and, therefore, can be interchangeable.  Conclusions:  The results observed that the multi-source tablets of Diazepam 10 mg included in this research are bioequivalent with the innovator and, therefore, allow the determination of pharmaceutical equivalence as a support element in the decision-making process for purchasing in the service pharmacist.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[diazepam]]></kwd>
<kwd lng="es"><![CDATA[intercambiabilidad]]></kwd>
<kwd lng="es"><![CDATA[bioequivalencia]]></kwd>
<kwd lng="en"><![CDATA[diazepam]]></kwd>
<kwd lng="en"><![CDATA[interchangeability]]></kwd>
<kwd lng="en"><![CDATA[bioequivalence]]></kwd>
</kwd-group>
</article-meta>
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