<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2340-9894</journal-id>
<journal-title><![CDATA[Ars Pharmaceutica (Internet)]]></journal-title>
<abbrev-journal-title><![CDATA[Ars Pharm]]></abbrev-journal-title>
<issn>2340-9894</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Granada]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2340-98942022000200178</article-id>
<article-id pub-id-type="doi">10.30827/ars.v63i2.21894</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Cimicifuga racemosa (L.) Nutt. en el tratamiento de los síntomas vasomotores de la menopausia: revisión]]></article-title>
<article-title xml:lang="en"><![CDATA[Cimicifuga racemosa (L.) Nutt. in the treatment of vasomotor symptoms of menopause: a review]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Bienes]]></surname>
<given-names><![CDATA[Hilaria M]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez-Mateo]]></surname>
<given-names><![CDATA[Candelaria C]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de La Laguna Facultad de Farmacia Departamento de Medicina Física y Farmacología]]></institution>
<addr-line><![CDATA[La Laguna Tenerife]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<volume>63</volume>
<numero>2</numero>
<fpage>178</fpage>
<lpage>188</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S2340-98942022000200178&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S2340-98942022000200178&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S2340-98942022000200178&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción:  Diversos estudios han puesto de manifiesto que los preparados a base de los rizomas y raíces de cimicífuga (Cimicifuga racemosa (L.) Nutt.) pueden ser útiles para aliviar los síntomas menopáusicos. El objetivo de este trabajo es realizar una revisión de la eficacia y seguridad de estos preparados en el tratamiento de los síntomas vasomotores de la menopausia.  Método:  Se realizó una búsqueda de los artículos publicados desde enero de 2005 a marzo de 2021 en el buscador de recursos de la Universidad de La Laguna, &#8220;el Punto Q&#8221;. Se seleccionaron los ensayos clínicos aleatorizados y controlados, que tuvieran las palabras claves en el resumen, texto o título, tanto en inglés como en español.  Resultados: Se identificaron 13 ensayos clínicos que incluían los criterios de selección establecidos. Se encontró que los preparados de cimicífuga (principalmente extractos comerciales estandarizados en su contenido en principios activos) produjeron en la mayoría de los estudios una reducción significativa comparada con el placebo de los síntomas vegetativos (sofocos y sudores nocturnos) y psicológicos de la menopausia, así como una mejoría de la calidad de vida. No se observaron efectos adversos serios a las dosis utilizadas.  Conclusiones: Los extractos de cimicífuga pueden ser eficaces y seguros para el tratamiento de los síntomas vegetativos y psicológicos de la menopausia, siendo bien tolerados. No obstante, son necesarios más ensayos clínicos con mayor número de pacientes, más extensos, uso de preparaciones estandarizadas, así como con criterios similares de inclusión y valoración de los síntomas, para obtener datos más concluyentes.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction:  Several studies have shown that preparations based on the rhizomes and roots of black cohosh (Cimicifuga racemosa (L.) Nutt.) can be useful in alleviating the menopausal symptoms. The aim of this study is to perform an update bibliographic review of the efficacy and safety of black cohosh in the treatment of the vasomotor symptoms of menopause.  Method:  A review of published articles from January 2005 to March 2021 in the resource search engine of the University of La Laguna, el punto Q&#8221;. Randomized and controlled clinical trials, which had the key words in the abstract, text or title, in both English and Spanish, were selected.  Results: We found 13 trials which met the selection criteria. The studies reviewed showed that the black cohosh preparations (mainly commercial extracts standardized in their content of active ingredients) produced in most of the studies a significant reduction compared to placebo in the vegetative (hot flashes and night sweats) and psychological symptoms of menopause, as well as an improvement in the quality of life. No serious adverse effects were reported at the dose administered.  Conclusions: Cimicifuga racemosa extracts can be effective and safe for the treatment of vegetative and psychological symptoms of menopause, being well tolerated. However, more clinical trials with a larger number of patients, more extensive, the use of standardized preparations, as well as similar criteria for inclusion and assessment of symptoms, are necessary to obtain more conclusive data.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Cimicifuga racemosa]]></kwd>
<kwd lng="es"><![CDATA[menopausia]]></kwd>
<kwd lng="es"><![CDATA[sofocos]]></kwd>
<kwd lng="es"><![CDATA[síntomas vasomotores]]></kwd>
<kwd lng="es"><![CDATA[revisión]]></kwd>
<kwd lng="en"><![CDATA[Cimicifuga racemosa]]></kwd>
<kwd lng="en"><![CDATA[menopause]]></kwd>
<kwd lng="en"><![CDATA[hot flushes]]></kwd>
<kwd lng="en"><![CDATA[vasomotor symptoms]]></kwd>
<kwd lng="en"><![CDATA[review]]></kwd>
</kwd-group>
</article-meta>
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<given-names><![CDATA[RE]]></given-names>
</name>
<name>
<surname><![CDATA[Malavasi]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Brundu]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Facchinetti]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Efficacy of Cimicifuga racemosa on climacteric complaents: a randomized study versus low-dose transdermal estradiol]]></article-title>
<source><![CDATA[Gynecological Endocrinol]]></source>
<year>2005</year>
<volume>20</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>30-5</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
