<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2340-9894</journal-id>
<journal-title><![CDATA[Ars Pharmaceutica (Internet)]]></journal-title>
<abbrev-journal-title><![CDATA[Ars Pharm]]></abbrev-journal-title>
<issn>2340-9894</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Granada]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2340-98942023000400006</article-id>
<article-id pub-id-type="doi">10.30827/ars.v64i4.28863</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Ecdiesteroides y su actividad farmacológica sobre el músculo esquelético]]></article-title>
<article-title xml:lang="en"><![CDATA[Ecdysteroids and their pharmacological activity on skeletal muscle]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Otero-Egocheaga]]></surname>
<given-names><![CDATA[Vicente]]></given-names>
</name>
</contrib>
</contrib-group>
<aff id="A">
<institution><![CDATA[,  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<volume>64</volume>
<numero>4</numero>
<fpage>376</fpage>
<lpage>384</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S2340-98942023000400006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S2340-98942023000400006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S2340-98942023000400006&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: Los ecdiesteroides presentan cualidades únicas dentro del reino vegetal y animal. Su similitud a esteroides endógenos de mamíferos les otorga actividad biológica sobre el tejido muscular esquelético. Sin embargo, su mecanismo de acción está por definirse en su totalidad.  Método: Se realizó una revisión narrativa utilizando la evidencia científica más relevante. Se consultaron de las bases de datos Medline, Google Scholar, Scielo y Wiley, incluyéndose y excluyéndose trabajos acordes a los criterios del autor.  Resultados: La actividad de los ecdiesteroides, principalmente de la Ecdisterona (Ec), podría deberse a la interacción con Mas, receptor acoplado a proteína-G transmembrana (GPCR), y la posterior activación del receptor de estrógenos &#946; (ER &#946;) no nuclear. Dicho mecanismo de acción induce la activación de la ruta alternativa del Sistema Renina-Angiotensina-Aldosterona (RAA) aboliendo los mecanismos de degradación muscular y, mediante la activación indirecta de Er&#946;, se suprime la expresión del gen de la miostatina. Esta actividad biológica pudiera conferir a los ecdiesteroides propiedades farmacológicas óptimas para impedir la degradación proteico-muscular, tales como la regeneración y reparación del tejido.  Conclusiones: Ec ha demostrado poseer propiedades farmacológicas interesantes para el abordaje alternativo de patologías musculodegenerativas por sus efectos anticatabólicos. Aunque prosigue la investigación para su implementación en la clínica, esta siendo utilizada en la industria deportiva y en ensayos para el tratamiento de diferentes patologías.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Ecdysteroids present unique qualities within the plant and animal kingdoms. Their similarity to endogenous mammalian steroids allows them to present biological activity on skeletal muscle tissue. However, this molecule&#8217;s action mechanism remains to be fully understood.  Method: A narrative review was carried out using the most relevant scientific evidence. Different databases such as Medline, Google Scholar, Scielo and Wiley were consulted. Works were included or excluded according to the author´s criterium.  Results: Ecdysteroids&#8217; activity, mostly that of ecdysterone, might be due to the interaction with Mas receptor, a transmembrane G-Protein Coupled Receptor (GPCR), and the subsequent indirect activation of &#946;-Estrogen Receptor´s (&#946;-ER) non-nuclear form. Said action mechanism induces the alternative pathway activation of the Renin-Angiotensin-Aldosterone System (RAAS), abolishing muscular degradation mechanism. Finally, through &#946;-ER activation, the myostatin gene is supressed. This biological activity could provide ecdysteroids optimal pharmacological properties to prevent muscular protein degradation. These include tissue regeneration and repair.  Conclusions: Due to its anticatabolic effects, Ec has shown great pharmacological properties that could make it work as an alternative treatment for degenerative muscle pathologies. Although investigations regarding Ec are still in progress, it has already been used by the sports&#8217; industry and in several clinical trials that focus on the treatment of other diseases.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Ecdiesteroides]]></kwd>
<kwd lng="es"><![CDATA[ecdisterona]]></kwd>
<kwd lng="es"><![CDATA[músculo esquelético]]></kwd>
<kwd lng="es"><![CDATA[receptor de estrógenos, receptor acoplado a proteína-G]]></kwd>
<kwd lng="es"><![CDATA[Receptor de Angiotensina (1-7) Mas]]></kwd>
<kwd lng="en"><![CDATA[Skeletal muscle]]></kwd>
<kwd lng="en"><![CDATA[Ecdysteroids]]></kwd>
<kwd lng="en"><![CDATA[Ecdysterone]]></kwd>
<kwd lng="en"><![CDATA[Angiotensin (1-7) Receptor Mas]]></kwd>
<kwd lng="en"><![CDATA[Estrogen Receptor]]></kwd>
<kwd lng="en"><![CDATA[G Protein Coupled Receptors]]></kwd>
</kwd-group>
</article-meta>
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