<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2340-9894</journal-id>
<journal-title><![CDATA[Ars Pharmaceutica (Internet)]]></journal-title>
<abbrev-journal-title><![CDATA[Ars Pharm]]></abbrev-journal-title>
<issn>2340-9894</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Granada]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2340-98942024000300008</article-id>
<article-id pub-id-type="doi">10.30827/ars.v65i3.30072</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Genes diferencialmente expresados en cáncer de pulmón de células pequeñas: potenciales dianas terapéuticas]]></article-title>
<article-title xml:lang="en"><![CDATA[Differentially expressed genes in small cell lung cancer: potential therapeutic targets]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jiménez-Sánchez]]></surname>
<given-names><![CDATA[Luis Esteban]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Internacional de las Américas Facultad de Ciencias de la Salud Escuela de Farmacia]]></institution>
<addr-line><![CDATA[San José ]]></addr-line>
<country>Costa Rica</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2024</year>
</pub-date>
<volume>65</volume>
<numero>3</numero>
<fpage>278</fpage>
<lpage>287</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S2340-98942024000300008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S2340-98942024000300008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S2340-98942024000300008&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: El cáncer de pulmón de células pequeñas (SCLC, por sus siglas en inglés) se caracteriza por una expectativa de vida desalentadora y una limitación en las opciones de tratamiento, por lo que la urgencia de encontrar nuevas dianas terapéuticas es considerable. En este contexto, la utilización de los análisis de expresión génica diferencial en células tumorales de SCLC ha permitido identificar genes anormalmente expresados que se asocian con el desarrollo y progresión de la enfermedad, lo cual puede contribuir al descubrimiento de potenciales dianas terapéuticas.  Método: Se realizó una revisión bibliográfica en las bases de datos PubMed, Science Direct, Google Scholar y Wiley, tras la cual se incluyeron 28 referencias.  Resultados: El análisis de la literatura reveló 37 genes diferencialmente expresados en SCLC involucrados en funciones biológicas críticas como la regulación del ciclo celular, señalización, transcripción y desarrollo embrionario. La expresión anormal de estos genes está asociada con consecuencias clínicas graves, como mal pronóstico, progresión del cáncer y resistencia a fármacos, resaltando el potencial de estos genes como posibles objetivos terapéuticos.  Conclusión: La comprensión detallada de la expresión génica diferencial en SCLC abre caminos prometedores para el desarrollo de terapias dirigidas y la identificación de estos genes anormalmente expresados como potenciales dianas terapéuticas representa un enfoque prometedor en la lucha contra esta forma letal de cáncer de pulmón.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Small cell lung cancer (SCLC) is characterized by a discouraging life expectancy and limited treatment options, so the urgency to find new therapeutic targets is considerable. In this context, the use of differential gene expression analyses in SCLC tumor cells has made it possible to identify abnormally expressed genes associated with the development and progression of the disease, which may contribute to the discovery of potential therapeutic targets.  Method: A literature review was carried out in the databases PubMed, Science Direct, Google Scholar and Wiley, after which 28 references were included.  Results: Literature analysis revealed 37 differentially expressed genes in SCLC, involved in critical biological functions such as cell cycle regulation, signaling, transcription and embryonic development. Abnormal expression of these genes is associated with serious clinical consequences, such as poor prognosis, cancer progression, and drug resistance, highlighting the potential of these genes as potential therapeutic targets.  Conclusion: Detailed understanding of differential gene expression in SCLC opens promising ways for development of targeted therapies and the identification of these abnormally expressed genes as potential therapeutic targets represents a promising approach in the fight against this lethal form of lung cancer.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Carcinoma Pulmonar de Células Pequeñas]]></kwd>
<kwd lng="es"><![CDATA[Perfilación de la Expresión Génica]]></kwd>
<kwd lng="es"><![CDATA[Diana terapéutica]]></kwd>
<kwd lng="en"><![CDATA[Small Cell Lung Carcinoma]]></kwd>
<kwd lng="en"><![CDATA[Gene Expression Profiling]]></kwd>
<kwd lng="en"><![CDATA[Therapeutic target]]></kwd>
</kwd-group>
</article-meta>
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