<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2529-850X</journal-id>
<journal-title><![CDATA[Journal of Negative and No Positive Results]]></journal-title>
<abbrev-journal-title><![CDATA[JONNPR]]></abbrev-journal-title>
<issn>2529-850X</issn>
<publisher>
<publisher-name><![CDATA[Research and Science S.L.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2529-850X2021000200012</article-id>
<article-id pub-id-type="doi">10.19230/jonnpr.3817</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Análisis de la relación entre diabetes mellitus tipo 2 y la obesidad con los factores de riesgo cardiovascular]]></article-title>
<article-title xml:lang="en"><![CDATA[Analysis of the relationship between type 2 diabetes mellitus and obesity with cardiovascular risk factors]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodriguez-Rada]]></surname>
<given-names><![CDATA[Cristina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Celada-Rodriguez]]></surname>
<given-names><![CDATA[Ángel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Celada-Roldán]]></surname>
<given-names><![CDATA[Carmen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tárraga-Marcos]]></surname>
<given-names><![CDATA[Mª Loreto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Romero-de Ávila]]></surname>
<given-names><![CDATA[Mario]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tárraga-López]]></surname>
<given-names><![CDATA[Pedro J]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Castilla la Mancha  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Castilla la Mancha  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Médico Familia de Cartagena  ]]></institution>
<addr-line><![CDATA[Murcia ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital Clínico de Zaragoza  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Hospital General de Almansa  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Universidad de Castilla la Mancha  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>6</volume>
<numero>2</numero>
<fpage>411</fpage>
<lpage>433</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S2529-850X2021000200012&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S2529-850X2021000200012&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S2529-850X2021000200012&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La &#8220;diabesidad&#8221; es un concepto en auge que hace referencia a los individuos con diabetes mellitus tipo 2 y obesidad. Ambos conceptos se encuentran íntimamente relacionados. Se ha llevado a cabo una búsqueda en Web Of Science para realizar una revisión bibliográfica con el objetivo de establecer la relación existente entre la obesidad, la diabetes mellitus tipo 2 y los factores de riesgo cardiovascular. El tejido adiposo es una glándula endocrina capaz de secretar hormonas, citoquinas y sustancias vasoactivas. En los individuos obesos, este tejido adiposo se muestra disfuncional, secretando de forma inusual ciertas adipocinas como la leptina y adiponectina. Tanto es así, que en individuos obesos sometidos a una cirugía bariátrica se ha visto como la relación adiponectina/leptina se invierte. Además, en un ambiente obesogénico, el tejido adiposo muestra un fenotipo proinflamatorio, que ayuda a perpetuar el proceso de resistencia a la insulina y el consiguiente desarrollo de prediabetes y diabetes mellitus tipo 2. Es importante determinar nuevas dianas terapéuticas para la diabesidad, como el factor de transcripción GPS2, que muestra una disminución de sus niveles en sujetos obesos, lo cual predispone a un fenotipo pro-diabético. Recientemente se ha demostrado que mi-483-5p se expresa en tejidos relevantes de diabetes y enfermedad cardiovascular, lo cual predice su potencial como biomarcador en sangre de dichas enfermedades. En conclusión, esta revisión pretende recalcar la importancia de controlar los factores de riesgo cardiovascular, como la obesidad, para impedir el desarrollo posterior de una enfermedad estrechamente ligada a ésta como es la diabetes tipo 2.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract &#8220;Diabesity&#8221; is a booming concept that refers to individuals with type 2 diabetes mellitus and obesity. Both concepts are closely related. A search of Web Of Science was carried out to carry out a bibliographic review with the aim of establishing the relationship between obesity, type 2 diabetes mellitus and cardiovascular risk factors. Adipose tissue is an endocrine gland capable of secreting hormones, cytokines, and vasoactive substances. In obese individuals, this adipose tissue is dysfunctional, secreting certain adipokines such as leptin and adiponectin in an unusual way. So much so, that in obese individuals undergoing bariatric surgery, the adiponectin / leptin ratio has been reversed. Furthermore, in an obesogenic environment, adipose tissue displays a proinflammatory phenotype, which helps perpetuate the process of insulin resistance and the consequent development of prediabetes and type 2 diabetes mellitus. It is important to determine new therapeutic targets for diabesity, such as the GPS2 transcription factor, which shows a decrease in its levels in obese subjects, which predisposes to a pro-diabetic phenotype. Mi-483-5p has recently been shown to be expressed in relevant tissues of diabetes and cardiovascular disease, which predicts its potential as a blood biomarker for these diseases. In conclusion, this review aims to emphasize the importance of controlling cardiovascular risk factors, such as obesity, to prevent the subsequent development of a disease closely related to it, such as type 2 diabetes.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[obesidad]]></kwd>
<kwd lng="es"><![CDATA[diabetes mellitus tipo 2]]></kwd>
<kwd lng="es"><![CDATA[diabesidad]]></kwd>
<kwd lng="es"><![CDATA[adipocinas]]></kwd>
<kwd lng="es"><![CDATA[riesgo cardiovascular]]></kwd>
<kwd lng="en"><![CDATA[obesity]]></kwd>
<kwd lng="en"><![CDATA[diabetes mellitus type 2]]></kwd>
<kwd lng="en"><![CDATA[diabesity]]></kwd>
<kwd lng="en"><![CDATA[adipokines]]></kwd>
<kwd lng="en"><![CDATA[cardiovascular risk]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schmidt]]></surname>
<given-names><![CDATA[AM.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Highlighting Diabetes Mellitus: The Epidemic Continues]]></article-title>
<source><![CDATA[Arterioscler Thromb Vasc Biol]]></source>
<year>2018</year>
<volume>38</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>E1-8</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Egocheaga]]></surname>
<given-names><![CDATA[MI]]></given-names>
</name>
<name>
<surname><![CDATA[Flores]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Sanchis]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Pepió]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Paja]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Nevado]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Iglesias]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Domínguez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ureña]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Bonet]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Dalfó]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Martín]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Estudio Steno2. Gaede P Vedel P Larsen N Jensen G Parving HH Pedersen O Multifactorial Interv Cardiovasc Dis Patients Type 2]]></article-title>
<source><![CDATA[Diabetes N Engl J Med]]></source>
<year>2003</year>
<volume>348</volume>
<page-range>383-93</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Castell Abat]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Lloveras Vallès]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[El estudio prospectivo inglés sobre diabetes (UKPDS): importantes respuestas, pero persisten muchas preguntas]]></article-title>
<source><![CDATA[Endocrinol Nutr]]></source>
<year>1999</year>
<volume>46</volume>
<numero>2</numero>
<issue>2</issue>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Drareni]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Ballaire]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Barilla]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[GPS2 Deficiency Triggers Maladaptive White Adipose Tissue Expansion in Obesity via HIF1A Activation]]></article-title>
<source><![CDATA[Cell Rep]]></source>
<year>2018</year>
<volume>24</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>2957-2971.e6</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kahn]]></surname>
<given-names><![CDATA[BB.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Adipose Tissue, Inter-Organ Communication, and the Path to Type 2 Diabetes: The 2016 Banting Medal for Scientific Achievement Lecture]]></article-title>
<source><![CDATA[Diabetes]]></source>
<year>2019</year>
<volume>68</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>3-14</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bonamichi]]></surname>
<given-names><![CDATA[BDSF]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Unusual Suspects in the Development of Obesity-Induced Inflammation and Insulin Resistance: NK cells, iNKT cells, and ILCs]]></article-title>
<source><![CDATA[Diabetes Metab J]]></source>
<year>2017</year>
<volume>41</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>229-50</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Villarroya]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Cereijo]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Gavalda-Navarro]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Villarroya]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Giralt]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inflammation of brown/beige adipose tissues in obesity and metabolic disease]]></article-title>
<source><![CDATA[J Intern Med]]></source>
<year>2018</year>
<volume>284</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>492-504</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Landecho]]></surname>
<given-names><![CDATA[MF]]></given-names>
</name>
<name>
<surname><![CDATA[Tuero]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Valenti]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Bilbao]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[de la Higuera]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Fruhbeck]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk]]></article-title>
<source><![CDATA[Nutrients]]></source>
<year>2019</year>
<volume>11</volume>
<numero>11</numero>
<issue>11</issue>
</nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Eckel]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Myokines in metabolic homeostasis and diabetes]]></article-title>
<source><![CDATA[Diabetologia]]></source>
<year>2019</year>
<volume>62</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1523-8</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Unamuno]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Izaguirre]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Gomez-Ambrosi]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Increase of the Adiponectin/Leptin Ratio in Patients with Obesity and Type 2 Diabetes after Roux-en-Y Gastric Bypass]]></article-title>
<source><![CDATA[Nutrients]]></source>
<year>2019</year>
<volume>11</volume>
<numero>9</numero>
<issue>9</issue>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Owei]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Umekwe]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Provo]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Wan]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Dagogo-Jack]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Insulin-sensitive and insulinresistant obese and non-obese phenotypes: role in prediction of incident pre-diabetes in a longitudinal biracial cohort]]></article-title>
<source><![CDATA[Bmj Open Diabetes Res Care]]></source>
<year>2017</year>
<volume>5</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gallo]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Esguerra]]></surname>
<given-names><![CDATA[JLS]]></given-names>
</name>
<name>
<surname><![CDATA[Eliasson]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Melander]]></surname>
<given-names><![CDATA[O.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[miR-483-5p associates with obesity and insulin resistance and independently associates with new onset diabetes mellitus and cardiovascular disease]]></article-title>
<source><![CDATA[Plos One]]></source>
<year>2018</year>
<volume>13</volume>
<numero>11</numero>
<issue>11</issue>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
