<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0212-1611</journal-id>
<journal-title><![CDATA[Nutrición Hospitalaria]]></journal-title>
<abbrev-journal-title><![CDATA[Nutr. Hosp.]]></abbrev-journal-title>
<issn>0212-1611</issn>
<publisher>
<publisher-name><![CDATA[Grupo Arán]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0212-16112018000100162</article-id>
<article-id pub-id-type="doi">10.20960/nh.1084</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Effect of fish and olive oil on mitochondrial ATPase activity and membrane fluidity in patients with relapsing-remitting multiple sclerosis treated with interferon beta 1-b]]></article-title>
<article-title xml:lang="es"><![CDATA[Efecto del aceite de pescado en la actividad hidrolítica de la ATPasa y en la fluidez de la membrana mitocondrial en pacientes con esclerosis múltiple remitente-recurrente tratados con interferón beta 1-b]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torres-Sánchez]]></surname>
<given-names><![CDATA[Erandis-D.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pacheco-Moisés]]></surname>
<given-names><![CDATA[Fermín-P.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Macias-Islas]]></surname>
<given-names><![CDATA[Miguel-A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morales-Sánchez]]></surname>
<given-names><![CDATA[Eddic-W.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez-Ramírez]]></surname>
<given-names><![CDATA[Viridiana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Celis-de-la-Rosa]]></surname>
<given-names><![CDATA[Alfredo-J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cid-Hernández]]></surname>
<given-names><![CDATA[Margarita]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sorto-Gómez]]></surname>
<given-names><![CDATA[Tanya-E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ortiz]]></surname>
<given-names><![CDATA[Genaro-G.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Mexican Social Security Institute (IMSS) West Biomedical Research Center (WBRC) Laboratory of Development-Aging, Neurodegenerative Diseases. Neuroscience Department]]></institution>
<addr-line><![CDATA[ Jalisco]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Autonomous University of Guadalajara Laboratory of Biochemistry Department of Chemistry. Center of Exact Sciences and Engineering]]></institution>
<addr-line><![CDATA[ Jalisco]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Autonomous University of Guadalajara Health Science Center Department of Pharmacology]]></institution>
<addr-line><![CDATA[ Jalisco]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Autonomous University of Guadalajara Health Science Center Public Department]]></institution>
<addr-line><![CDATA[ Jalisco]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>02</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>02</month>
<year>2018</year>
</pub-date>
<volume>35</volume>
<numero>1</numero>
<fpage>162</fpage>
<lpage>168</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S0212-16112018000100162&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S0212-16112018000100162&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S0212-16112018000100162&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background:  Multiple sclerosis (MS) is an inflammatory disease of the central nervous system associated with increased oxidative stress (OS) and mitochondrial alterations. Fish oil consumption has neuroprotective, antioxidant and anti-inflammatory effects in patients with relapsing-recurrent MS (RR-MS).  Objective:  To evaluate changes in the hydrolytic activity of ATP synthase and mitochondrial membrane fluidity in patients with RR-MS who receive fish oil or olive oil as a dietary supplement.  Methods:  Clinical, controlled, randomized, double-blind trial. Patients consumed fish oil or olive oil for one year. The hydrolytic activity of ATPase and the fluidity of the mitochondrial membrane of platelets were quantified.  Results:  In patients with RR-MS, a decrease in the fluidity of mitochondrial membranes and an increase in the hydrolytic activity of ATP synthase was observed in comparison with healthy controls. After 6 or 9 months of treatment with fish oil or olive oil, respectively, these values were normalized.  Conclusion:  The consumption of fish oil and olive oil increases the fluidity of the mitochondrial membranes and decreases the catabolic activity of ATP synthase in platelets from patients with RR-MS.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción:  la esclerosis múltiple (EM) es una enfermedad inflamatoria del sistema nervioso central asociada con estrés oxidativo (EO) y alteraciones mitocondriales. El aceite de pescado tiene efectos neuroprotectores, antioxidantes y antiinflamatorios en pacientes con EM remitente-recurrente (EM-RR).  Objetivo:  evaluar los cambios en la actividad hidrolítica de la ATPasa y de la fluidez de membrana mitocondrial en pacientes con EM-RR que reciben aceite de pescado o aceite de oliva como suplemento alimenticio.  Métodos:  ensayo clínico, controlado, aleatorizado, doble ciego. Los pacientes consumieron aceite de pescado o aceite de oliva durante un año. Se cuantificó la actividad hidrolítica de la ATPasa y la fluidez de la membrana mitocondrial de plaquetas.  Resultados:  en pacientes con EM-RR hay una disminución de la fluidez de las membranas mitocondriales y un incremento de la actividad hidrolítica de la ATPasa en comparación con controles sanos. Después de 6 y 9 meses de tratamiento con aceite de oliva y de aceite de pescado, respectivamente, los valores se normalizaron y se mantuvieron así hasta el fin del estudio.  Conclusión:  el consumo de aceite de pescado y aceite de oliva incrementan la fluidez de membrana y disminuye la actividad catabólica de la ATP sintasa en pacientes con EM-RR.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Multiple sclerosis]]></kwd>
<kwd lng="en"><![CDATA[Mitochondrial ATPase]]></kwd>
<kwd lng="en"><![CDATA[Membranal fluidity]]></kwd>
<kwd lng="en"><![CDATA[Olive oil]]></kwd>
<kwd lng="en"><![CDATA[Fish oil]]></kwd>
<kwd lng="es"><![CDATA[Esclerosis múltiple]]></kwd>
<kwd lng="es"><![CDATA[ATPasa mitocondrial]]></kwd>
<kwd lng="es"><![CDATA[Fluidez membranal]]></kwd>
<kwd lng="es"><![CDATA[Aceite de oliva]]></kwd>
<kwd lng="es"><![CDATA[Aceite de pescado]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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