Mediterranean diet is associated with liver histology in patients with non alcoholic fatty liver disease
La dieta mediterránea se asocia con la histología hepática en pacientes con enfermedad del hígado graso no alcohólico
Rocio Aller1,2, Olatz Izaola1,3, Beatriz de la Fuente1 and Daniel de Luis1,3
1Center of Investigation of Endocrinology and Nutrition, Medicine School.
2Dept Gastroenterology and Hepatology.
3Dept of Endocrinology and Nutrition. Hospital Clínico Universitario. University of Valladolid, Valladolid, Spain.
ABSTRACT
Background: clinical data on impact of the Mediterranean diet on the the stage of non alcoholic fatty liver disease are limited and these studies have heterogeneous designs.
Aim: we decide to explore any potential associations between adherence to the Mediterranean diet and histological characteristics of patients with NAFLD.
Methods: a sample of 82 patients was analyzed in a cross sectional study. To evaluate the level of adherence to the Mediterranean dietary pattern the 14-Item Mediterranean Diet Assessment Tool was used.
Results: thirty five patients (42.7%) had a low grade of steatosis (grade 1 of classification) and 47 patients (57.3%) had a high grade of steatosis (grade 2 and 3). Fifty-six patients (68.3%) had liver steatohepatitis and forty-two patients (51.2%) had liver fibrosis. In the logistic regresion analysis, one unit of the 14-Item Mediterranean Diet Assessment Tool was associated with a lower likehood of having steatohepatitis odds ratio 0.43 (CI:95%: 0.29-0.64) and steatosis 0.42 (CI:95%: 0.26- 0.70). Secondly, one unit of HOMA-IR was associated with higher likehood of having steatosis odds ratio 2.01 (CI:95%: 1.08-3.71) and liver fibrosis 1.38 (CI:95%: 1.10-1.80) .
Conclusions: greater adherence to the Mediterranean diet was associated with lower likelihood of high grade of steatosis and presence of steatohepatitis.
Key words: Insulin resistance. Mediterranean diet. Nonalcoholic fatty liver disease. Liver biopsy.
RESUMEN
]]> Antecedentes: los datos clínicos sobre el impacto de la dieta mediterránea en el estadio de la enfermedad son limitados, y los estudios existentes tienen diseños heterogéneos.Palabras clave: Resistencia a la insulina. Dieta mediterránea. Hígado graso no alcohólico. Biopsia hepática.
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