Introduction:

Drug-induced thrombocytopenia is an adverse effect whose incidence is unknown, but which can be potentially severe.

Patients and methods:

The cases of two patients with thrombocytopenia associated with ceftaroline and/or daptomycin used in association in the treatment of infective endocarditis due to methicillin-resistant Staphylococcus aureus (MRSA) are presented.

Results:

In the two cases described, a decrease in the platelet count is shown during the combined treatment, continuing the effect despite the dose reduction and being associated with ceftaroline due to the drug/effect temporal sequence. Both cases were notified to the Pharmacovigilance Service. The causality assessment of ceftaroline using the Karch Lasagna algorithm modified by Naranjo et al. was possible in the first case and probable in the second.

Conclusions:

Given the two cases described and others collected in the literature review on the risk of thrombocytopenia associated with ceftaroline, it is necessary to carry out haematological controls, especially in patients with prolonged treatments and/or with high doses. Post-authorization studies are necessary to assess the incidence of rare adverse effects.

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