Abstract

RUIBAL, A.; SANCHEZ SALMON, A.; ARGIBAY, S.  and  RODRIGUEZ, J.. Valor clínico-biológico de la concentración citosólica de ácido hialurónico en adenocarcinomas pulmonares CD44v6 positivos. Oncología (Barc.) [online]. 2005, vol.28, n.1, pp.45-50. ISSN 0378-4835.

PURPOSE: To study the influence of the cytosol hyaluronic acid (HA) concentrations on the clinical and biological features of CD44v6-positive lung adenocarcinomas (LAs). MATERIAL AND METHODS: The study included 34 tissue samples. We determined the concentration of HA, p52, cathepsin D, t-PA, NSE, cyfra 21.1, CA125, and free beta subunit of human chorionic gonadotrophin in the cytosol, and of EGFR, erbB2 oncoprotein, CD44s and CD44v5 on the cell surface. Other parameters considered were clinical stage, histological grade (HG), ploidy, DNA index, and S-phase cell fraction (SF) measured by flow cytometry. RESULTS: In the tumoral group the HA/CD44v6 index values varied from 8.5 to 5,999 (107, median for the entire group) and were significantly higher (p 0.004) than those observed in 10 samples of normal lung tissue obtained from the same patients. The HA/CD44v6-positive (>107) adenocarcinomas had higher concentrations of erbB2 oncoprotein (p: 0.02), and greater values of global SF (p: 0.009) and DNA index (p: 0.024). They were also more frequently SF+ (>15 %). CONCLUSIONS: The results stand out the importance of the cytosol concentration of hyalurinic acid in the CD44v6-positive lung adenocarcinomas, in such a way that high values of the HA/CD44v6 index are associated with a higher proliferation and cellular undifferentiation, which, joined to the higher concentration of erbB2 protein, suggest a subgroup of tumors with a possibly different (poorer ?) outcome. Nevertheless, given the limited number of studied patients, further studies are necessary to confirm our findings.

Keywords : CD44v6; Hyaluronic acid; Lung adenocarcinoma; Cell proliferation; Hyalurinic acid/CD44v6 index.

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